Enhanced identification of endocrine disruptors through integration of science-based regulatory practices and innovative methodologies: The MERLON Project.

Autor:	Svingen T; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Andersson AM; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Angelova J; Health and Environment Alliance (HEAL), Brussels, Belgium., Axelstad M; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Bakker J; Neuroendocrinology Laboratory, GIGA-Neurosciences, University of Liege, Liege, Belgium., Baumann L; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands., Beronius A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden., Bouftas N; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands., Chalmel F; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France., Christiansen S; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Cornil C; Neuroendocrinology Laboratory, GIGA-Neurosciences, University of Liege, Liege, Belgium., Damdimopoulou P; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, 14186, Sweden.; Department of Gynecology and Reproductive Medicine, Karolinska Institutet, Huddinge, 14186, Sweden., Deepika D; IISPV, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalonia, 43007, Spain., Dollé MET; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Draskau MK; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Fischer MB; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Hagen CP; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Hessel E; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Holmer ML; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Hughes S; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands., Jensen G; Health and Environment Alliance (HEAL), Brussels, Belgium., Johansson HKL; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Juul A; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Kumar V; IISPV, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalonia, 43007, Spain., Kumar S; IISPV, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Tarragona, Catalonia, 43007, Spain., Lardenois A; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France., Main KM; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Mazaud-Guittot S; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France., Moe SJ; Norwegian Institute for Water Research (NIVA), Oslo, 0579, Norway., Mola G; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.; International Center for Research and Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark., Parent AS; Neuroendocrinology Laboratory, GIGA-Neurosciences, University of Liege, Liege, Belgium., Pineda R; Department of Cell Biology, Physiology and Immunology / IMIBIC., University of Cordoba, Cordoba, 14012, Spain., Rolland A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden., Rosenmai AK; National Food Institute, Technical University of Denmark, Kgs. Lyngby, Region Hovedstaden, 2800, Denmark., Song Y; Norwegian Institute for Water Research (NIVA), Oslo, 0579, Norway., Suglia A; Univ Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail), Rennes, F-25000, France., Tena-Sempere M; Department of Cell Biology, Physiology and Immunology / IMIBIC., University of Cordoba, Cordoba, 14012, Spain., Wehrli L; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, 14186, Sweden.; Department of Gynecology and Reproductive Medicine, Karolinska Institutet, Huddinge, 14186, Sweden., Zilliacus J; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 17177, Sweden., van Duursen M; Environmental Health and Toxicology, Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, Amsterdam, North Holland, 2800, The Netherlands.
Jazyk:	angličtina
Zdroj:	Open research Europe [Open Res Eur] 2024 Apr 12; Vol. 4, pp. 68. Date of Electronic Publication: 2024 Apr 12 (Print Publication: 2024).
DOI:	10.12688/openreseurope.17319.1
Abstrakt:	The prevalence of hormone-related health issues caused by exposure to endocrine disrupting chemicals (EDCs) is a significant, and increasing, societal challenge. Declining fertility rates together with rising incidence rates of reproductive disorders and other endocrine-related diseases underscores the urgency in taking more action. Addressing the growing threat of EDCs in our environment demands robust and reliable test methods to assess a broad variety of endpoints relevant for endocrine disruption. EDCs also require effective regulatory frameworks, especially as the current move towards greater reliance on non-animal methods in chemical testing puts to test the current paradigm for EDC identification, which requires that an adverse effect is observed in an intact organism. Although great advances have been made in the field of predictive toxicology, disruption to the endocrine system and subsequent adverse health effects may prove particularly difficult to predict without traditional animal models. The MERLON project seeks to expedite progress by integrating multispecies molecular research, new approach methodologies (NAMs), human clinical epidemiology, and systems biology to furnish mechanistic insights and explore ways forward for NAM-based identification of EDCs. The focus is on sexual development and function, from foetal sex differentiation of the reproductive system through mini-puberty and puberty to sexual maturity. The project aims are geared towards closing existing knowledge gaps in understanding the effects of EDCs on human health to ultimately support effective regulation of EDCs in the European Union and beyond. Competing Interests: No competing interests were disclosed. (Copyright: © 2024 Svingen T et al.)
Databáze:	MEDLINE
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