Coexistence of myasthenia gravis and lichen planus: A case report and systematic review of related case reports from 1971 to 2024.

Autor: Jameie M; Iranian Center of Neurological Research, Neuroscience Institute Tehran University of Medical Sciences Tehran Iran., Amanollahi M; School of Medicine Tehran University of Medical Sciences Tehran Iran., Ahli B; School of Medicine Tehran University of Medical Sciences Tehran Iran., Farahmand G; Neurology Department, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran., Magrouni H; Neurology Department, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran., Sarraf P; Iranian Center of Neurological Research, Neuroscience Institute Tehran University of Medical Sciences Tehran Iran.; Neurology Department, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran.
Jazyk: angličtina
Zdroj: Clinical case reports [Clin Case Rep] 2024 Jun 14; Vol. 12 (6), pp. e9065. Date of Electronic Publication: 2024 Jun 14 (Print Publication: 2024).
DOI: 10.1002/ccr3.9065
Abstrakt: Key Clinical Message: The co-occurrence of myasthenia gravis (MG) and lichen planus (LP) is a rare phenomenon, with only 13 cases reported in the English literature between 1971 and 2024. Patients with MG or LP, regardless of the thymoma status, require close monitoring for other autoimmune diseases.
Abstract: Myasthenia gravis (MG) is an uncommon autoimmune disease, resulting in fatigable muscle weakness in the ocular, bulbar, and respiratory muscles, as well as muscles of the extremities. Lichen planus (LP) is an autoimmune mucocutaneous disease, presenting with pruritic and violaceous plaques on the skin and mucosal surfaces. So far, MG and LP co-occurrence is only reported in anecdotal individuals. This study reports a patient with MG and LP and systematically reviews the English literature on this rare co-occurrence from 1971 to 2024, indicating only 13 cases with similar conditions. A 67-year-old man presented with ocular and progressive bulbar symptoms, a year after being diagnosed with generalized LP. Laboratory evaluations were normal except for the high anti-AchR-Ab titer and a positive ANA titer. Neurologic examinations revealed asymmetric bilateral ptosis, weakness and fatigability in proximal muscles, and a severe reduction in the gag reflex. He was diagnosed with late-onset, seropositive MG. The treatment included pyridostigmine (60 mg, three times daily), intravenous immunoglobulin (25 g daily for 5 days), and oral prednisolone. There was no evidence of thymoma in the chest x-ray and CT scan without contrast. However, a CT scan with contrast was not performed due to the patient's unstable condition. A common autoimmune mechanism may underlie the unclear pathophysiology of MG and LP co-occurrence, with or without thymoma. Patients with MG, LP, or thymoma require close monitoring and assessment for other possible autoimmune diseases.
Competing Interests: The author has no conflicts of interest to declare.
(© 2024 The Author(s). Clinical Case Reports published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje