Comparative Evaluation of Remineralizing Potential of Topical Cream Containing Casein Phosphopeptide-Amorphous Calcium Phosphate and Casein Phosphopeptide-Amorphous Calcium Phosphate with Fluoride: An In Vitro Study.

Autor:	Rajendran R; Department of Conservative and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India., Antonys DP; Department of Conservative and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India., Faizal N; Medical Service Department, Ministry of Interior, Qatar., Oommen S; Department of Prosthodontics, Noorul Islam College of Dental Sciences, Neyattinkara, Kerala, India., Vijayasree G; Department of Conservative Dentistry and Endodontics, Avenues Multispeciality Dental Centre, Ernakulam, Kerala, India., Ashik PM; Department of Conservative Dentistry and Endodontics, KMCT Dental College, Manassery, Kozhikode, Kerala, India.
Jazyk:	angličtina
Zdroj:	Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2024 Apr; Vol. 16 (Suppl 2), pp. S1801-S1804. Date of Electronic Publication: 2024 Apr 16.
DOI:	10.4103/jpbs.jpbs_1148_23
Abstrakt:	The requirement for clinically effective treatments to remineralize early enamel caries lesions is dictated by the principles of minimally invasive dentistry. Numerous studies outlined the significance of treating early carious lesions with different remineralizing agents. This study aimed to evaluate and compare the remineralization potential of topical cream containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and CPP-ACP with fluoride in remineralizing artificial carious lesions on enamel. Forty-five freshly extracted human premolar teeth were selected as samples. These samples were divided into three groups: Group I-regular toothpaste without specific remineralizing agent; Group II-topical cream containing CPP-ACP and Group III topical cream containing CPP-ACP with fluoride. All the samples were viewed under scanning electron microscope (SEM) to assess the topographical pictures of the enamel surface and also subjected to energy dispersing X-ray analysis (EDX) for quantitative estimation of minerals, calcium (Ca), and phosphorous (P). In the result of the study, Group I does not show any increase in the Ca and P after applying toothpaste without any remineralizing agent but Group II and Group III showed a net increase in Ca and P- values after applying concerned remineralizing agents. Intergroup comparison showed Group III yielded higher net Ca and P- values than Group II. Two remineralizing agents showed remineralization potential on samples. Descriptive statistics were used to calculate the mean and standard deviation. Mann-Whitney test was used. The level of significance was set at 0.05. CPP-ACP containing fluoride showed better remineralizing potential than CPP-ACP. Hence, CPP-ACP containing fluoride can be considered the material of choice in remineralizing early enamel carious lesions. Competing Interests: There are no conflicts of interest. (Copyright: © 2024 Journal of Pharmacy and Bioallied Sciences.)
Databáze:	MEDLINE
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