[Analysis of intracranial saccular aneurysm wall: neuroimaging and histopathological correlates].

Autor:	Semin KS; Burdenko Neurosurgical Center, Moscow, Russia., Demyashkin GA; Sechenov First Moscow State Medical University, Moscow, Russia., Zakharova NE; Burdenko Neurosurgical Center, Moscow, Russia., Eliava SS; Burdenko Neurosurgical Center, Moscow, Russia., Kheireddin AS; Burdenko Neurosurgical Center, Moscow, Russia., Konovalov AN; Burdenko Neurosurgical Center, Moscow, Russia., Kalaeva DB; Burdenko Neurosurgical Center, Moscow, Russia., Batalov AI; Burdenko Neurosurgical Center, Moscow, Russia., Pronin IN; Burdenko Neurosurgical Center, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 2024; Vol. 88 (3), pp. 52-58.
DOI:	10.17116/neiro20248803152
Abstrakt:	Background: Contrast enhancement of intracranial aneurysm wall during MRI with targeted visualization of vascular wall correlates with previous aneurysm rupture and, according to some data, may be a predictor of further rupture of unruptured aneurysms. Objective: To analyze possible causes of aneurysm contrast enhancement considering morphological data of aneurysm walls. Material and Methods: The study included 44 patients with intracranial aneurysms who underwent preoperative MRI between November 2020 and September 2022. Each aneurysm was assessed regarding contrast enhancement pattern. Microsurgical treatment of aneurysm was accompanied by resection of its wall for subsequent histological and immunohistochemical analysis regarding thrombosis, inflammation and neovascularization. Specimens were subjected to histological and immunochemical analysis. Immunohistochemical analysis was valuable to estimate inflammatory markers CD68 and CD3, as well as neurovascularization marker SD31. Results: Aneurysms with contrast-enhanced walls were characterized by higher number of CD3+, CD68+, CD31+ cells and parietal clots. Intensity of contrast enhancement correlated with aneurysm wall abnormalities. Conclusion: Contrast enhancement of aneurysm wall can characterize various morphological abnormalities.
Databáze:	MEDLINE
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