Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil.

Autor: Amakran A; Laboratoire de Biochimie et Génétique Moléculaire, Faculté des Sciences et Techniques, Université Abdelmalek Essaadi, Tanger, Maroc., Hamoudane M; Laboratoire de Biochimie et Génétique Moléculaire, Faculté des Sciences et Techniques, Université Abdelmalek Essaadi, Tanger, Maroc., Pagniez F; Nantes Université, CHU Nantes, Cibles et Médicaments des Infections et de l'Immunité, IICiMed, UR 1155, F-44000, Nantes, France., Lamarti A; Laboratoire de Biotechnologie et d'Amélioration des Plantes, Département de Biologie, Faculté des Sciences, Université Abdelmalek Essaadi, Tétouan, Maroc., Picot C; Nantes Université, CHU Nantes, Cibles et Médicaments des Infections et de l'Immunité, IICiMed, UR 1155, F-44000, Nantes, France., Figueredo G; Laboratoire d'Analyse des Extraits Végétaux et des Aromes (LEXVA-Analytique), Biopôle Clermont-Limagne, Rue Henri Mondor, 63360, Sain-Beauzire, France., Nhiri M; Laboratoire de Biochimie et Génétique Moléculaire, Faculté des Sciences et Techniques, Université Abdelmalek Essaadi, Tanger, Maroc., Le Pape P; Nantes Université, CHU Nantes, Cibles et Médicaments des Infections et de l'Immunité, IICiMed, UR 1155, F-44000, Nantes, France.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Sep; Vol. 21 (9), pp. e202300563. Date of Electronic Publication: 2024 Aug 10.
DOI: 10.1002/cbdv.202300563
Abstrakt: This study aimed to define the chemical composition of Moroccan Thymus capitatus essential oil, and to investigate its in vitro antioxidant and antifungal activities against human pathogenic fungi. Chemical analysis using GC-FID and GC-MS system revealed 28 constituents, representing 99 % of total compounds. Oxygenated monoterpenes represented the highest proportion (79.79 %), among which carvacrol (75.73 %) was the predominant compound, followed by linalol (2.26 %). Monoterpene hydrocarbons represented the second major fraction (16.29 %): within them, the predominant constituents were γ-terpinene (5,55 %), ρ-cymene (5,50 %), and β-caryophyllene (2.73 %). Antioxidant activity was performed by DPPH scavenging, β-carotene bleaching inhibition, and ferric reducing power. T. capitatus revealed pronounced DPPH radical scavenging activity (IC 50 =110.53 μg mL -1 ), strong ferric reducing ability (EC 50 =644.4 μg mL -1 ), and a remarkable degree of protection against lipid peroxidation during β-carotene bleaching inhibition (IC 50 =251.76 μg mL -1 ). Antifungal activity was carried out against Candida, Aspergillus, and Rhizopus species by microdilution method. T. capitatus exhibited potent anticandidal activity (MIC=125-500 μg mL -1 ) and strong inhibition against filamentous fungi (MIC=250-500 μg mL -1 ). Its hemolytic activity against human erythrocytes had a low toxic effect at concentrations lower than 1250 μg mL -1 . The useful antioxidant properties and broad antifungal effect of T. capitatus EO confirm its considerable potential for the food industry and for phytopharmaceutical production.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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