Clinical Validation of Digitally Acquired Clinical Data and Machine Learning Models for Remote Measurement of Psoriasis and Psoriatic Arthritis: A Proof-of-Concept Study.
| Autor: | Webster DE; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., Haberman RH; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA., Perez-Chada LM; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Tummalacherla M; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., Tediarjo A; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., Yadav V; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., Neto EC; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., MacDuffie W; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., DePhillips M; M. DePhillips, BS, E. Sieg, BS, SDP Digital, Seattle, Washington, USA., Sieg E; M. DePhillips, BS, E. Sieg, BS, SDP Digital, Seattle, Washington, USA., Catron S; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA., Grant C; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Francis W; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Nguyen M; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Yussuff M; L.M. Perez-Chada, MD, MMSc, C. Grant, BS, W. Francis, BS, M. Nguyen, BS, M. Yussuff, BS, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Castillo RL; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA., Yan D; D. Yan, MD, A.L. Neimann, MD, MSCE, Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA., Neimann AL; D. Yan, MD, A.L. Neimann, MD, MSCE, Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA., Reddy SM; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA., Ogdie A; A. Ogdie, MD, MSCE, Department of Medicine, Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Kolivras A; A. Kolivras, MD, PhD, Departments of Dermatology and Dermatopathology, Saint-Pierre, Brugmann and Queen Fabiola Children University Hospitals, Université Libre de Bruxelles, Brussels, and UCB Pharma, Brussels, Belgium., Kellen MR; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., Mangravite LM; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., Sieberts SK; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., Omberg L; D.E. Webster, PhD, M. Tummalacherla, MSE, A. Tediarjo, BS, V. Yadav, MS, E. Chaibub Neto, PhD, W. MacDuffie, MS, M.R. Kellen, PhD, L.M. Mangravite, PhD, S.K. Sieberts, PhD, L. Omberg, PhD, Sage Bionetworks, Seattle, Washington, USA., Merola JF; J.F. Merola, MD, MMSc, Department of Dermatology and Department of Medicine, Division of Rheumatology, UT Southwestern Medical Center, Dallas, Texas, USA., Scher JU; R.H. Haberman, MD, MSCI, S. Catron, BS, R.L. Castillo, MD, MSCI, S.M. Reddy, MD, J.U. Scher, MD, Department of Medicine, Division of Rheumatology, New York University Grossman School of Medicine and NYU Psoriatic Arthritis Center, NYU Langone Health, New York, New York, USA; Jose.Scher@nyulangone.org. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of rheumatology [J Rheumatol] 2024 Aug 01; Vol. 51 (8), pp. 781-789. Date of Electronic Publication: 2024 Aug 01. |
| DOI: | 10.3899/jrheum.2024-0074 |
| Abstrakt: | Objective: Psoriatic disease remains underdiagnosed and undertreated. We developed and validated a suite of novel, sensor-based smartphone assessments (Psorcast app) that can be self-administered to measure cutaneous and musculoskeletal signs and symptoms of psoriatic disease. Methods: Participants with psoriasis (PsO) or psoriatic arthritis (PsA) and healthy controls were recruited between June 5, 2019, and November 10, 2021, at 2 academic medical centers. Concordance and accuracy of digital measures and image-based machine learning models were compared to their analogous clinical measures from trained rheumatologists and dermatologists. Results: Of 104 study participants, 51 (49%) were female and 53 (51%) were male, with a mean age of 42.3 years (SD 12.6). Seventy-nine (76%) participants had PsA, 16 (15.4%) had PsO, and 9 (8.7%) were healthy controls. Digital patient assessment of percent body surface area (BSA) affected with PsO demonstrated very strong concordance (Lin concordance correlation coefficient [CCC] 0.94 [95% CI 0.91-0.96]) with physician-assessed BSA. The in-clinic and remote target plaque physician global assessments showed fair-to-moderate concordance (CCC Conclusion: The Psorcast digital assessments achieved significant clinical validity, although they require further validation in larger cohorts before use in evidence-based medicine or clinical trial settings. The smartphone software and analysis pipelines from the Psorcast suite are open source and freely available. (Copyright © 2024 by the Journal of Rheumatology.) |
| Databáze: | MEDLINE |
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