Cognitive effects of piracetam in adults with memory impairment: A systematic review and meta-analysis.

Autor: Gouhie FA; Faculty of Medicine, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil. Electronic address: felipegouhie@ufu.br., Barbosa KO; Faculty of Medicine, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Cruz ABR; Faculty of Medicine, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Wellichan MM; Faculty of Medicine, Federal University of Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil., Zampolli TM; Faculty of Medicine, Pernambuco University (UPE), Recife, Pernambuco, Brazil.
Jazyk: angličtina
Zdroj: Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2024 Aug; Vol. 243, pp. 108358. Date of Electronic Publication: 2024 May 31.
DOI: 10.1016/j.clineuro.2024.108358
Abstrakt: Introduction: Piracetam, a widely recognized nootropic drug, is hypothesized to enhance memory function through its influence on synaptic plasticity and neurotransmitter levels. However, despite its popularity, there remains a lack of conclusive evidence regarding its impact on memory. Therefore, the present study aims to explore the effects of piracetam on memory in individuals with impaired cognitive function, comparing it to a placebo control group.
Objectives: This study will evaluate how piracetam affects memory function, compared to placebo in adults with impairment in this area.
Methods: We carried out bibliographical research and meta-analysis of scientific clinical trials comparing memory function in people taking piracetam with those in the placebo group. The PubMed, Dimensions, Embase, and Cochrane Library databases were used. Statistical analysis was performed in R Studio version 4.3.1.
Results: In our analysis, 199 articles were identified, of which we included eighteen studies, comprising a total of 886 patients, of which Piracetam was the treatment option in 442 (49.88 %) patients. Memory enhancement (SMD 0.75; 95 % CI [-0.19; 1.69]; p=0.12; I²=96 %) had no clinical difference between the intervention and the control group.
Conclusion: Upon the conclusion of this study, it is apparent that we cannot definitively ascertain the impact of piracetam on memory function. Further research is warranted to provide a clearer understanding of the cognitive effects of piracetam in individuals with memory impairment. This investigation serves as a significant contribution to the ongoing quest to elucidate the potential benefits of piracetam in the field of cognitive neuroscience.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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