The roles of TonEBP in the DNA damage response: From DNA damage bypass to R-loop resolution.

Autor: Choi SY; Department of Biology, Jeju National University, Jeju, the Republic of Korea. Electronic address: sychoi@jejunu.ac.kr.
Jazyk: angličtina
Zdroj: DNA repair [DNA Repair (Amst)] 2024 Aug; Vol. 140, pp. 103697. Date of Electronic Publication: 2024 May 29.
DOI: 10.1016/j.dnarep.2024.103697
Abstrakt: Tonicity-responsive enhancer binding protein (TonEBP) is a stress-responsive protein that plays a critical role in the regulation of gene expression and cellular adaptation to stressful environments. Recent studies uncovered the novel role of TonEBP in the DNA damage response, which significantly impacts genomic stability. This review provides a comprehensive overview of the novel role of TonEBP in DNA damage repair, including its involvement in the DNA damage bypass pathway and the recognition and resolution of DNA damage-induced R-loop structures.
Competing Interests: Declaration of Competing Interest The author declares that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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