Hybrid crystalline bioparticles with nanochannels encapsulating acemannan from Aloe vera: Structure and interaction with lipid membranes.

Autor: Madrid RRM; Laboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, 04023-062 Sao Paulo, Brazil., Mathews PD; Laboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, 04023-062 Sao Paulo, Brazil; Institute of Biosciences, Sao Paulo State University, 18618-689 Botucatu, Brazil., Pramanik S; Max Planck Institute of Colloids and Interfaces, Science Park Golm, 14476 Potsdam, Germany., Mangiarotti A; Max Planck Institute of Colloids and Interfaces, Science Park Golm, 14476 Potsdam, Germany., Fernandes R; Applied Physics Department, Institute of Physics, University of Sao Paulo, 05508-900 Sao Paulo, Brazil., Itri R; Applied Physics Department, Institute of Physics, University of Sao Paulo, 05508-900 Sao Paulo, Brazil., Dimova R; Max Planck Institute of Colloids and Interfaces, Science Park Golm, 14476 Potsdam, Germany. Electronic address: Rumiana.Dimova@mpikg.mpg.de., Mertins O; Laboratory of Nano Bio Materials (LNBM), Department of Biophysics, Paulista Medical School, Federal University of Sao Paulo, 04023-062 Sao Paulo, Brazil. Electronic address: mertins@unifesp.br.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2024 Nov; Vol. 673, pp. 373-385. Date of Electronic Publication: 2024 Jun 10.
DOI: 10.1016/j.jcis.2024.06.073
Abstrakt: Smart nanocarrier-based bioactive delivery systems are a current focus in nanomedicine for allowing and boosting diverse disease treatments. In this context, the design of hybrid lipid-polymer particles can provide structure-sensitive features for tailored, triggered, and stimuli-responsive devices. In this work, we introduce hybrid cubosomes that have been surface-modified with a complex of chitosan-N-arginine and alginate, making them pH-responsive. We achieved high-efficiency encapsulation of acemannan, a bioactive polysaccharide from Aloe vera, within the nanochannels of the bioparticle crystalline structure and demonstrated its controlled release under pH conditions mimicking the gastric and intestinal environments. Furthermore, an acemannan-induced phase transition from Im3m cubic symmetry to inverse hexagonal H II phase enhances the bioactive delivery by compressing the lattice spacing of the cubosome water nanochannels, facilitating the expulsion of the encapsulated solution. We also explored the bioparticle interaction with membranes of varying curvatures, revealing thermodynamically driven affinity towards high-curvature lipid membranes and inducing morphological transformations in giant unilamellar vesicles. These findings underscore the potential of these structure-responsive, membrane-active smart bioparticles for applications such as pH-triggered drug delivery platforms for the gastrointestinal tract, and as modulators and promoters of cellular internalization.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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