Analysis of T follicular and T peripheral helper lymphocytes in autoimmune thyroid disease.

Autor: Sánchez-Gutiérrez R; Section of Molecular and Translational Medicine, CICSaB, UASLP, 78210, San Luis Potosí, SLP, México., Martínez-Hernández R; Service of Endocrinology, Hospital Universitario de La Princesa, Instituto de Investigación Princesa, Universidad Autónoma de Madrid, Madrid, España., Serrano-Somavilla A; Service of Endocrinology, Hospital Universitario de La Princesa, Instituto de Investigación Princesa, Universidad Autónoma de Madrid, Madrid, España., Sampedro-Nuñez M; Service of Endocrinology, Hospital Universitario de La Princesa, Instituto de Investigación Princesa, Universidad Autónoma de Madrid, Madrid, España., Mendoza-Pérez A; Section of Molecular and Translational Medicine, CICSaB, UASLP, 78210, San Luis Potosí, SLP, México., de Nova JLM; Service of Endocrinology, Hospital Universitario de La Princesa, Instituto de Investigación Princesa, Universidad Autónoma de Madrid, Madrid, España., Vitales-Noyola M; Section of Molecular and Translational Medicine, CICSaB, UASLP, 78210, San Luis Potosí, SLP, México., González-Amaro R; Section of Molecular and Translational Medicine, CICSaB, UASLP, 78210, San Luis Potosí, SLP, México.; Department of Immunology, School of Medicine, UASLP, 78210, San Luis Potosí, SLP, México., Marazuela M; Service of Endocrinology, Hospital Universitario de La Princesa, Instituto de Investigación Princesa, Universidad Autónoma de Madrid, Madrid, España. monica.marazuela@uam.es.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2024 Nov; Vol. 86 (2), pp. 699-706.
DOI: 10.1007/s12020-024-03686-7
Abstrakt: Purpose: Peripheral helper T (Tph) cells have an important role in the induction of humoral immune responses and autoantibody production. Accordingly, it is feasible that this lymphocyte subset has a relevant role in the pathogenesis of autoimmune thyroid diseases (AITD). In this study we aim to analyze the levels and function of Tph cells in blood samples from patients with AITD.
Methods: We performed an observational study with cases and controls. Blood samples were obtained from nineteen patients with Hashimoto's thyroiditis (HT), twenty-four with Graves' disease (GD), and fifteen healthy controls. In addition, the levels of follicular T helper (Tfh) cells and Tph cells, the release of interleukin-21 (IL-21) by these lymphocytes and the number of plasmablasts were analyzed by multi-parametric flow cytometry analyses.
Results: Increased percentages of Tfh and Tph lymphocytes were detected in patients with HT and GD. Furthermore, an enhanced synthesis of the cytokine IL-21 by these cells was observed. Accordingly, we detected significant higher percentages of plasmablasts in patients with GD, and these values tended to be also higher in HT patients. Moreover, significant positive associations were observed between the levels of Tfh or Tph and the number of plasmablast or anti-TSHR Ab titers in patients with AITD.
Conclusion: Our data suggest that Tph lymphocytes may have a relevant role in the pathogenesis of AITD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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