Beta Oscillations in the Sensory Thalamus During Severe Facial Neuropathic Pain Using Novel Sensing Deep Brain Stimulation.

Autor: Lopez Ramos CG; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA. Electronic address: lopezrac@ohsu.edu., Rockhill AP; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA., Shahin MN; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA., Gragg A; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA., Tan H; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA., Yamamoto EA; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA., Fecker AL; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA., Ismail M; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA., Cleary DR; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA., Raslan AM; Department of Neurological Surgery, Oregon Health & Science University, Portland, OR, USA.
Jazyk: angličtina
Zdroj: Neuromodulation : journal of the International Neuromodulation Society [Neuromodulation] 2024 Jun 15. Date of Electronic Publication: 2024 Jun 15.
DOI: 10.1016/j.neurom.2024.05.003
Abstrakt: Objective: Advancements in deep brain stimulation (DBS) devices provide a unique opportunity to record local field potentials longitudinally to improve the efficacy of treatment for intractable facial pain. We aimed to identify potential electrophysiological biomarkers of pain in the ventral posteromedial nucleus (VPM) of the thalamus and periaqueductal gray (PAG) using a long-term sensing DBS system.
Materials and Methods: We analyzed power spectra of ambulatory pain-related events from one patient implanted with a long-term sensing generator, representing different pain intensities (pain >7, pain >9) and pain qualities (no pain, burning, stabbing, and shocking pain). Power spectra were parametrized to separate oscillatory and aperiodic features and compared across the different pain states.
Results: Overall, 96 events were marked during a 16-month follow-up. Parameterization of spectra revealed a total of 62 oscillatory peaks with most in the VPM (77.4%). The pain-free condition did not show any oscillations. In contrast, β peaks were observed in the VPM during all episodes (100%) associated with pain >9, 56% of episodes with pain >7, and 50% of burning pain events (center frequencies: 28.4 Hz, 17.8 Hz, and 20.7 Hz, respectively). Episodes of pain >9 indicated the highest relative β band power in the VPM and decreased aperiodic exponents (denoting the slope of the power spectra) in both the VPM and PAG.
Conclusions: For this patient, an increase in β band activity in the sensory thalamus was associated with severe facial pain, opening the possibility for closed-loop DBS in facial pain.
Competing Interests: Conflict of Interest The authors reported no conflict of interest.
(Copyright © 2024 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: