Association between Epstein-Barr virus LMP-1 and Hodgkin lymphoma LMP-1 mechanisms in Hodgkin lymphoma development.

Autor: Oliveira LOD; Virology Section, Evandro Chagas Institute, Ananindeua, Pará, Brazil., Costa IB; Virology Section, Evandro Chagas Institute, Ananindeua, Pará, Brazil., Quaresma JAS; Federal University of Pará, Belém, Pará, Brazil.
Jazyk: angličtina
Zdroj: Reviews in medical virology [Rev Med Virol] 2024 Jul; Vol. 34 (4), pp. e2561.
DOI: 10.1002/rmv.2561
Abstrakt: Hodgkin lymphoma is histologically characterised by the presence of Hodgkin (H) and Reed-Sternberg (RS) cells originating from germinal centre B-cells rearranged in the IgV gene. The formation of multinucleated RS cells is a product of telomere organisation in a process initiated by telomere aggregate accumulation in mononuclear H cells and may be mediated by latent membrane protein 1 (LMP-1) expression. LMP-1 is the main oncoprotein of EBV and supports several tumourigenic processes. LMP-1 may rescue proapoptotic B-cells through downregulation of B-cell receptor (BCR) components, mimicking and inducing multiple distinct B-cell signalling pathways to promote proliferation and survival, such as Janus kinase-signal transducer and activator of transcription (JAK-STAT), nuclear factor-kappa b (NF-кB), and cellular MYC (c-MYC), and inducing telomere instability mainly through Telomere repeat binding factor 2 (TRF2) downregulation to promote the formation of multinucleated RS cells. This review presents recent discoveries regarding the influence of LMP-1 on the surviving cellular signalling, genomic instability and mecanical formation of HRS cells.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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