Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans.

Autor: Hajnal B; Epilepsy Center, Clinic for Neurosurgery and Neurointervention, Semmelweis University, Budapest, 1145, Hungary.; János Szentágothai Neurosciences Program, Semmelweis University School of PhD Studies, Budapest, 1083, Hungary., Szabó JP; Epilepsy Center, Clinic for Neurosurgery and Neurointervention, Semmelweis University, Budapest, 1145, Hungary.; János Szentágothai Neurosciences Program, Semmelweis University School of PhD Studies, Budapest, 1083, Hungary.; Lendület Laboratory of Systems Neuroscience, HUN-REN Institute of Experimental Medicine, Budapest, 1083, Hungary., Tóth E; Epilepsy and Cognitive Neurophysiology Laboratory, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Keller CJ; Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.; Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine and Feinstein Institute of Medical Research, 300 Community Drive, Manhasset, NY, 11030, USA.; Department of Neuroscience, Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, 94304, USA., Wittner L; Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, HUN-REN, Budapest, 1117, Hungary.; Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, 1083, Hungary., Mehta AD; Department of Neurosurgery, Hofstra North Shore LIJ School of Medicine and Feinstein Institute of Medical Research, 300 Community Drive, Manhasset, NY, 11030, USA., Erőss L; Department of Functional Neurosurgery, Clinic for Neurosurgery and Neurointervention, Semmelweis University, Budapest, 1145, Hungary., Ulbert I; Epilepsy Center, Clinic for Neurosurgery and Neurointervention, Semmelweis University, Budapest, 1145, Hungary.; Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, HUN-REN, Budapest, 1117, Hungary.; Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, 1083, Hungary., Fabó D; Epilepsy Center, Clinic for Neurosurgery and Neurointervention, Semmelweis University, Budapest, 1145, Hungary. fabo.daniel@gmail.com., Entz L; Department of Functional Neurosurgery, Clinic for Neurosurgery and Neurointervention, Semmelweis University, Budapest, 1145, Hungary.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 14; Vol. 14 (1), pp. 13784. Date of Electronic Publication: 2024 Jun 14.
DOI: 10.1038/s41598-024-62433-0
Abstrakt: Cortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgical evaluation of epileptic patients. Nevertheless, the cortical generators underlying the various components of CCEPs in humans have not yet been elucidated. Our aim was to describe the laminar pattern arising under SPES evoked CCEP components (P1, N1, P2, N2, P3) and to evaluate the similarities between N2 and the downstate of sleep slow waves. We used intra-cortical laminar microelectrodes (LMEs) to record CCEPs evoked by 10 mA bipolar 0.5 Hz electric pulses in seven patients with medically intractable epilepsy implanted with subdural grids. Based on the laminar profile of CCEPs, the latency of components is not layer-dependent, however their rate of appearance varies across cortical depth and stimulation distance, while the seizure onset zone does not seem to affect the emergence of components. Early neural excitation primarily engages middle and deep layers, propagating to the superficial layers, followed by mainly superficial inhibition, concluding in a sleep slow wave-like inhibition and excitation sequence.
(© 2024. The Author(s).)
Databáze: MEDLINE
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