Sepsis mortality prediction with Machine Learning Tecniques.

Autor: Pérez-Tome JC; Department of Nursing: Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain., Parrón-Carreño T; Department of Nursing: Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain., Castaño-Fernández AB; Department of Applied Mathematics, University of Almería, 04120 Almeria, Spain., Nievas-Soriano BJ; Department of Nursing: Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain., Castro-Luna G; Department of Nursing: Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain. Electronic address: graciacl@ual.es.
Jazyk: angličtina
Zdroj: Medicina intensiva [Med Intensiva (Engl Ed)] 2024 Oct; Vol. 48 (10), pp. 584-593. Date of Electronic Publication: 2024 Jun 13.
DOI: 10.1016/j.medine.2024.05.009
Abstrakt: Objective: To develop a sepsis death classification model based on machine learning techniques for patients admitted to the Intensive Care Unit (ICU).
Design: Cross-sectional descriptive study.
Setting: The Intensive Care Units (ICUs) of three Hospitals from Murcia (Spain) and patients from the MIMIC III open-access database.
Patients: 180 patients diagnosed with sepsis in the ICUs of three hospitals and a total of 4559 patients from the MIMIC III database.
Main Variables of Interest: Age, weight, heart rate, respiratory rate, temperature, lactate levels, partial oxygen saturation, systolic and diastolic blood pressure, pH, urine, and potassium levels.
Results: A random forest classification model was calculated using the local and MIMIC III databases. The sensitivity of the model of our database, considering all the variables classified as important by the random forest, was 95.45%, the specificity was 100%, the accuracy was 96.77%, and an AUC of 95%. . In the case of the model based on the MIMIC III database, the sensitivity was 97.55%, the specificity was 100%, and the precision was 98.28%, with an AUC of 97.3%.
Conclusions: According to random forest classification in both databases, lactate levels, urine output and variables related to acid.base equilibrium were the most important variable in mortality due to sepsis in the ICU. The potassium levels were more critical in the MIMIC III database than the local database.
(Copyright © 2024 The Author(s). Published by Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE