In vitro toxicity and chemical analysis of e-cigarette aerosol produced amid dry hitting.

Autor: Beard JM; Department of Biology, Baylor University, Waco, TX 76798-7266, USA., Collom C; Department of Environmental Science, Baylor University, Waco, TX 76798-7266, USA., Liu JY; Department of Environmental Science, Baylor University, Waco, TX 76798-7266, USA., Obiako P; Department of Environmental Science, Baylor University, Waco, TX 76798-7266, USA., Strongin RM; Department of Chemistry, Portland State University, Portland, OR 97207, USA., Zavala J; MedTec Biolab, Inc., Durham, NC 27705, USA., Sayes CM; Department of Biology, Baylor University, Waco, TX 76798-7266, USA; Department of Environmental Science, Baylor University, Waco, TX 76798-7266, USA. Electronic address: Christie_sayes@baylor.edu.
Jazyk: angličtina
Zdroj: Toxicology [Toxicology] 2024 Aug; Vol. 506, pp. 153865. Date of Electronic Publication: 2024 Jun 13.
DOI: 10.1016/j.tox.2024.153865
Abstrakt: Dry hitting, a phenomenon produced by e-cigarettes with refillable cartridges when the liquid in the coil is low, is a common occurrence among regular vapers despite being an unintended consequence of the device. This phenomenon's hazard to public health is still unknown and needs further investigation. Lung cells cultured at the air-liquid interface were exposed to vaped aerosol consisting of 3 % w/v ethyl maltol in propylene glycol for three-second puffs every 30 seconds for 80 total puffs with either dry hit or saturated conditions. Cytotoxicity was measured colorimetrically. The thermal degradation of the heating coils and wicks was visualized using scanning electron microscopy. The chemical byproducts in the aerosol were analyzed using proton nuclear magnetic resonance and inductively coupled plasma mass spectrometry. The results revealed a highly significant increase in cytotoxicity from dry hit treatments. Imaging showed thermal decomposition of the cotton wick after dry hitting, which was confirmed by energy dispersive x-ray spectroscopy with less oxygen in the dry hit cotton. Chemical byproducts were found via unique peaks in the dry hit condensate in the aromatic and alkene regions. Saturated condensate showed higher concentrations of detected metal species than dry-hit condensate. E-cigarette users should avoid dry hitting by refilling tanks or cartridges preemptively or by using disposable coils to avoid increased toxicity during vaping.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Christie Sayes reports financial support was provided by Baylor University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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