Electronic nose based analysis of exhaled volatile organic compounds spectrum reveals asthmatic shifts and consistency in controls post-exercise and spirometry.

Autor:	Dragonieri S; Respiratory Diseases, University of Bari, Bari, Italy., Marco MD; Respiratory Diseases, University of Bari, Bari, Italy., Ahroud M; Respiratory Diseases, University of Bari, Bari, Italy., Quaranta VN; Respiratory Diseases, University of Bari, Bari, Italy., Portacci A; Respiratory Diseases, University of Bari, Bari, Italy., Iorillo I; Respiratory Diseases, University of Bari, Bari, Italy., Montagnolo F; Respiratory Diseases, University of Bari, Bari, Italy., Carpagnano GE; Respiratory Diseases, University of Bari, Bari, Italy.
Jazyk:	angličtina
Zdroj:	Journal of breath research [J Breath Res] 2024 Jun 26; Vol. 18 (3). Date of Electronic Publication: 2024 Jun 26.
DOI:	10.1088/1752-7163/ad5864
Abstrakt:	Analyzing exhaled volatile organic compounds (VOCs) with an electronic nose (e-nose) is emerging in medical diagnostics as a non-invasive, quick, and sensitive method for disease detection and monitoring. This study investigates if activities like spirometry or physical exercise affect exhaled VOCs measurements in asthmatics and healthy individuals, a crucial step for e-nose technology's validation for clinical use. The study analyzed exhaled VOCs using an e-nose in 27 healthy individuals and 27 patients with stable asthma, before and after performing spirometry and climbing five flights of stairs. Breath samples were collected using a validated technique and analyzed with a Cyranose 320 e-nose. In healthy controls, the exhaled VOCs spectrum remained unchanged after both lung function test and exercise. In asthmatics, principal component analysis and subsequent discriminant analysis revealed significant differences post-spirometry (vs. baseline 66.7% cross validated accuracy [CVA], p < 0.05) and exercise (vs. baseline 70.4% CVA, p < 0.05). E-nose measurements in healthy individuals are consistent, unaffected by spirometry or physical exercise. However, in asthma patients, significant changes in exhaled VOCs were detected post-activities, indicating airway responses likely due to constriction or inflammation, underscoring the e-nose's potential for respiratory condition diagnosis and monitoring. (© 2024 IOP Publishing Ltd.)
Databáze:	MEDLINE
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