| Autor: |
Rose MB; Fertility Medical Group. São Paulo - SP, Brazil.; Urology Department - Pontifícia Universidade Católica de Campinas - PUCAMP. Campinas - SP, Brazil., Sicard AB; Urology Department - Pontifícia Universidade Católica de Campinas - PUCAMP. Campinas - SP, Brazil., Aguiar NA; Urology Department - Pontifícia Universidade Católica de Campinas - PUCAMP. Campinas - SP, Brazil., Onório BO; Urology Department - Pontifícia Universidade Católica de Campinas - PUCAMP. Campinas - SP, Brazil., Almendra AAR; Urology Department - Pontifícia Universidade Católica de Campinas - PUCAMP. Campinas - SP, Brazil., Matheus WE; Urology Department - Universidade Estadual de Campinas - UNICAMP. Campinas - SP, Brazil., Garolla A; Unit of Andrology and Reproductive Medicine, Department of Medicine - University of Pandova. Pandova - PD, Italy., Foresta C; Unit of Andrology and Reproductive Medicine, Department of Medicine - University of Pandova. Pandova - PD, Italy., Braga DPAF; Fertility Medical Group. São Paulo - SP, Brazil., Setti AS; Fertility Medical Group. São Paulo - SP, Brazil., Borges E Jr; Fertility/FERTGROUP-Medicina Reprodutiva. São Paulo - SP, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
JBRA assisted reproduction [JBRA Assist Reprod] 2024 Aug 26; Vol. 28 (3), pp. 521-525. Date of Electronic Publication: 2024 Aug 26. |
| DOI: |
10.5935/1518-0557.20240039 |
| Abstrakt: |
Non-obstructive azoospermia (NOA) is the most severe form of male factor infertility. It results form from either primary or secondary testicular failure. Here, we report cases of two patients with NOA due to maturation arrest and increased serum FSH, treated with GnRH agonist and gonadotrophins. The two NOA patients underwent a pharmacological treatment consisting of pituitary desensibilization using a GnRH agonist and testicular stimulation using menotropin. Testicular stimulation started one month after the beginning of GnRH agonist treatment. The female partner underwent controlled ovarian stimulation (COS) followed by intracytoplasmic sperm injection (ICSI). On the third day of the cycle, menotropin daily doses was administered. When at least one follicle ≥14 mm was visualized, pituitary blockage was performed using GnRH antagonist ganirelix. When three or more follicles attained a mean diameter of ≥17 mm, triptorelin acetate was administered to trigger final follicular maturation. Oocyte retrieval was performed 35 hours later. After treatment, male partner blood levels of the FSH, LH, decreased and total testosterone were increased. Spermatozoa was observed after semen collection in both cases. After COS, oocytes were retrieved and ICSI was performed. Embryos were biopsied for preimplantation genetic testing (PGT) and those considered euploidy were transferred resulting in positive implantation, ongoing pregnancy, and livebirth on both cases. In this report we present a successful strategy for hypergonadotropic hypogonadism AOA men, as an alternative approach to the surgical testicular sperm recovery. Nevertheless, prospective randomized trials are needed to confirm our findings. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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