Associations of Plasma Tau with Amyloid and Tau PET: Results from the Community-Based Framingham Heart Study.

Autor:	Ramos-Cejudo J; Department of Psychiatry, New York University (NYU) Grossman School of Medicine, New York, NY, USA., Scott MR; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Tanner JA; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Pase MP; Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, Australia.; Harvard T.H. Chan School of Public Health, Boston, MA, USA., McGrath ER; HRB Clinical Research Facility, University of Galway, Galway, Ireland.; The Framingham Study, Boston, MA, USA.; School of Medicine, University of Galway, Galway, Ireland., Ghosh S; The Framingham Study, Boston, MA, USA., Osorio RS; Department of Psychiatry, New York University (NYU) Grossman School of Medicine, New York, NY, USA., Thibault E; Department of Radiology, Harvard Medical School, Boston, MA, USA., El Fakhri G; Department of Radiology, Harvard Medical School, Boston, MA, USA., Johnson KA; Department of Radiology, Harvard Medical School, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Beiser A; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; The Framingham Study, Boston, MA, USA.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Seshadri S; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; The Framingham Study, Boston, MA, USA.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 100 (2), pp. 487-494.
DOI:	10.3233/JAD-231320
Abstrakt:	Background: Associations of plasma total tau levels with future risk of AD have been described. Objective: To examine the extent to which plasma tau reflects underlying AD brain pathology in cognitively healthy individuals. Methods: We examined cross-sectional associations of plasma total tau with 11C-Pittsburgh Compound-B (PiB)-PET and 18F-Flortaucipir (FTP)-PET in middle-aged participants at the community-based Framingham Heart Study. Results: Our final sample included 425 participants (mean age 57.6± 9.9, 50% F). Plasma total tau levels were positively associated with amyloid-β deposition in the precuneus region (β±SE, 0.11±0.05; p = 0.025). A positive association between plasma total tau and tau PET in the rhinal cortex was suggested in participants with higher amyloid-PET burden and in APOEɛ4 carriers. Conclusions: Our study highlights that plasma total tau is a marker of amyloid deposition as early as in middle-age.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu