Analysis of risk factors for fatty liver disease in children with Wilson's disease.

Autor: Jia SP; Nanjing University of Chinese Medicine, Jiangsu Province.; Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province., Wang MX; Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province., Tao Z; Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province., Gao YN; Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province., Yu GR; Encephalopathy Department, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province, China., Yang WM; Encephalopathy Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Anhui Province.
Jazyk: angličtina
Zdroj: European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2024 Aug 01; Vol. 36 (8), pp. 1046-1053. Date of Electronic Publication: 2024 Jun 10.
DOI: 10.1097/MEG.0000000000002801
Abstrakt: Background and Aims: Many children with Wilson's disease are complicated with dyslipidemia. The aim of this study was to investigate the risk factors for the development of fatty liver disease (FLD) in children with Wilson's disease.
Methods: We evaluated sex, age, weight, the disease course, treatment course, clinical classification, alanine transaminase (ALT), aspartate transaminase, γ-glutamyl transpeptidase, total biliary acid, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, homocysteine, uric acid, fibrinogen (FBG), creatinine, procollagen III N-terminal propeptide, laminin, hyaluronic acid, type IV collagen, and performed receiver operating characteristic curve analysis to investigate the forecast value of individual biochemical predictors and combined predictive indicators to evaluate FLD in Wilson's disease.
Results: The multivariate logistic regression analysis revealed that ALT [odds ratio (OR), 1.011; 95% confidence interval (CI), 1.004-1.02; P  = 0.006], uric acid (OR, 1.01; 95% CI, 1.002-1.018; P  = 0.017), FBG (OR, 3.668; 95% CI, 1.145-13.71; P  = 0.037), creatinine (OR, 0.872; 95% CI, 0.81-0.925; P  < 0.001), and laminin (OR, 1.01; 95% CI, 1.002-1.018; P  = 0.017) acted as independent risk factors in Wilson's disease complicated with FLD. The receiver operating characteristic curves for combined predictive indicators demonstrated an area under the curve values of 0.872, which was found to be a significant predictors for FLD in Wilson's disease.
Conclusions: We screened out the most important risk factors, namely ALT, uric acid, creatinine, FBG, and laminin for Wilson's disease complicated with FLD. The joint prediction achieved is crucial for identifying children with Wilson's disease complicated with FLD.
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Databáze: MEDLINE