Understanding the HPV associated cancers: A comprehensive review.

Autor: Balhara N; Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, 124001, India., Yadav R; Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, 124001, India. yritu3757@gmail.com., Ranga S; Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, 124001, India., Ahuja P; Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, 124001, India., Tanwar M; Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Jazyk: angličtina
Zdroj: Molecular biology reports [Mol Biol Rep] 2024 Jun 14; Vol. 51 (1), pp. 743. Date of Electronic Publication: 2024 Jun 14.
DOI: 10.1007/s11033-024-09680-6
Abstrakt: Human papillomavirus (HPV), a common cause of sexually transmitted diseases, may cause warts and lead to various types of cancers, which makes it important to understand the risk factors associated with it. HPV is the leading risk factor and plays a crucial role in the progression of cervical cancer. Viral oncoproteins E6 and E7 play a pivotal role in this process. Beyond cervical cancer, HPV-associated cancers of the mouth and throat are also increasing. HPV can also contribute to other malignancies like penile, vulvar, and vaginal cancers. Emerging evidence links HPV to these cancers. Research on the oncogenic effect of HPV is still ongoing and explorations of screening techniques, vaccination, immunotherapy and targeted therapeutics are all in progress. The present review offers valuable insight into the current understanding of the role of HPV in cancer and its potential implications for treatment and prevention in the future.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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