Phototherapy for the treatment of atopic dermatitis in Singaporean children and adolescents.

Autor: Chia SY; Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore, Singapore.; Department of Dermatology, KK Women's and Children's Hospital, Singapore, Singapore., Chee EEC; Department of Dermatology, KK Women's and Children's Hospital, Singapore, Singapore., Wee LWY; Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore, Singapore.; Department of Dermatology, KK Women's and Children's Hospital, Singapore, Singapore., Koh MJA; Department of Dermatology, KK Women's and Children's Hospital, Singapore, Singapore.
Jazyk: angličtina
Zdroj: Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2024 Jul; Vol. 40 (4), pp. e12986.
DOI: 10.1111/phpp.12986
Abstrakt: Background/purpose: Phototherapy has emerged as a safe yet effective form of treatment of atopic dermatitis (AD). Few studies have been done to evaluate the efficacy of phototherapy in Asian children. The aim of this study was to review the phototherapy experience in a cohort of Asian pediatric patients with AD at a tertiary dermatologic center in Singapore.
Methods: A retrospective study of patients 18 years and below with AD who had undergone phototherapy at KK Women's and Children's Hospital, Singapore, over a 4-year period was performed.
Results: Sixty-two patients were identified, between ages 4 and 16 years (mean age 11 years) at the time of commencement of phototherapy. Thirty-five (60%) patients were males and 23 (40%) were females. Most patients had moderate to severe disease, with 60.3% of the patients with an initial body surface area (BSA) involvement of 31%-60% and 13.8% of the patients with an initial BSA involvement of 61%-90%. For patients who had undergone narrowband ultraviolet B (NBUVB) and combined ultraviolet A (UVA) and NBUVB phototherapy, the mean reduction of the Eczema Area and Severity Index (EASI) scores were 11.4 and 7.9, respectively. Common side effects experienced include xerosis, pruritus, erythema, and pain. Other reasons for cessation of therapy in the NBUVB group included time commitment difficulty (9.3%), hyperactivity (2.3%), and claustrophobia (2.3%). Two patients that had photochemotherapy (psoralen + UVA) [PUVA] suffered from post-UVA burns requiring cessation of treatment. More than half of the patients (56.9%) treated with phototherapy experienced treatment success with improvement in Investigator Global Assessment and EASI scores. 86.2% of the patients had good compliance to the treatment regime, 12% had poor-compliance, and 3.4% were lost to follow-up.
Conclusion: Phototherapy is a useful treatment adjunct for moderate to severe AD in Asian children.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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