Case report: Pilomatrix carcinoma with PDL1 expression and CDKN2A aberrant.

Autor:	Abula A; The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.; Department of Oncology, Turpan City People's Hospital, Tulufan, China., Ma SQ; The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.; Department of Oncology, Turpan City People's Hospital, Tulufan, China., Wang S; Department of Oncology, Turpan City People's Hospital, Tulufan, China.; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China., Peng W; The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.; Department of General Surgery, Turpan City People's Hospital, Tulufan, China., Pei X; The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.; Department of Urinary Surgery, Turpan City People's Hospital, Tulufan, China., Hu ZY; The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.; Department of Oncology, Turpan City People's Hospital, Tulufan, China.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 May 28; Vol. 15, pp. 1337400. Date of Electronic Publication: 2024 May 28 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1337400
Abstrakt:	Case Report: A 55-year-old male patient developed a mass in the left inguinal area with left lower limb swelling and first visited a local hospital 3 months earlier because of unrelieved pain. An MRI scan suggested left suprapubic branch and left acetabular bone destruction, abnormal soft tissue signals within the iliopsoas muscle of the anterior edge of the left iliac bone, and enlarged lymph nodes in the left iliac fossa and left inguinal region. The patient subsequently underwent left pelvic lesion open biopsy and inguinal lymph node resection biopsy. According to pathological reports, the left inguinal mass was considered to be a malignant tumor of cutaneous accessory origin (pilomatrix carcinoma) with extensive vitreous changes. The suprapupubis branch mass was considered to be a bone metastatic pilomatrix carcinoma. Immunohistochemistry (IHC) revealed a PDL1 combined positive score (CPS) of 8. DNA next-generation sequencing (NGS) showed CDKN2A L65Rfs*53 mutation. The patient received three cycles of gemcitabine and nedaplatin. However, the lesion progressed. Conclusion: Chemotherapy is not effective for treating pilomatrix carcinoma. PDL1 antibodies and CDK4/6 inhibitors might be treatment options for pilomatrix carcinoma. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Abula, Ma, Wang, Peng, Pei and Hu.)
Databáze:	MEDLINE
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