The Association of Sperm DNA Fragmentation With Serum Lipid Profile Among Males With Abnormal Semen Parameters: An Analytical Cross-Sectional Study.

Autor:	Thankamoni RK; Anatomy, Velammal Medical College Hospital and Research Institute, Madurai, IND., Tamgire DW; Anatomy, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND., Dasari P; Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND., Adole PS; Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND., Jinkala S; Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND., Ns K; Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND., Murugiah V; Biochemistry, Velammal Medical College Hospital and Research Institute, Madurai, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 May 13; Vol. 16 (5), pp. e60243. Date of Electronic Publication: 2024 May 13 (Print Publication: 2024).
DOI:	10.7759/cureus.60243
Abstrakt:	Background: Through the ages, infertility, affecting 8% to 12% of couples worldwide, has been a perturbing clinical problem. Approximately 40% to 50% of all infertility cases are due to 'male factor' infertility. Semen analysis is crucial in routinely evaluating idiopathic male infertility. Studies support the idea that semen parameters are associated with serum lipids and sperm DNA fragmentation (SDF). Therefore, it is possible to evaluate male infertility by serum lipid levels, especially before assisted reproduction technology, and modify it by bringing about lifestyle modifications. This study aimed to measure the correlation of SDF with levels of total cholesterol (TC), triglycerides (TG), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) among males with abnormal semen parameters. Methods: A cross-sectional analytical study was conducted in the infertility clinic of a tertiary care hospital. A total of 106 infertile males with abnormal semen analysis as per the WHO criteria (2010) were enrolled in the study. After routine semen analysis, SDF was studied using the comet assay. The serum fasting lipid profile was analyzed using the spectrophotometric kit in the autoanalyzer. The relationship of SDF with serum lipid profile parameters was analyzed. Results: Out of 106 infertile men, 52% (n = 55) had severe SDF. A modest positive correlation was observed between SDF (percentage of DNA in comet tail) and serum lipid values (serum TG, serum LDL, and serum VLDL). Conclusions: Our study is novel in its research on the correlation between SDF and serum lipid values. Based on the findings of our study, it can be concluded that a significant level of SDF was observed in men with high levels of serum TG, LDL, and VLDL. This provokes a potential relationship between sperm DNA integrity and serum lipid profile, which warrants further research. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Thankamoni et al.)
Databáze:	MEDLINE
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