The anti-hyperplasia effect of polysaccharide from Prunella vulgaris L. on mammary gland hyperplasia in rats through regulation of the AKT-FOXO3a signaling pathway and intestinal flora.

Autor: Zhao H; College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China., Yang Y; College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China., Zhou Y; College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China., Wen H; College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China., Chen C; College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China., Li C; College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China., Feng Y; College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China., Li L; College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China., Li X; College of Pharmacy, Jiamusi University, Jiamusi, People's Republic of China.; Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial, Key Laboratory for Research and Development of Tropical Herbs, Haikou Key Laboratory of Li Nationality Medicine, School of Pharmacy, Hainan Medical University, Haikou, People's Republic of China.; Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, Cardiovascular Diseases Institute of First Affiliated Hospital, Hainan Medical University, Haikou, People's Republic of China.
Jazyk: angličtina
Zdroj: Journal of the science of food and agriculture [J Sci Food Agric] 2024 Oct; Vol. 104 (13), pp. 8190-8200. Date of Electronic Publication: 2024 Jun 14.
DOI: 10.1002/jsfa.13652
Abstrakt: Background: Prunella vulgaris L., a medicinal and edible homologous plant, is often used to treat conditions such as breast hyperplasia, thyroid enlargement and lymphatic tuberculosis. Research has demonstrated that it is particularly effective in the treatment of mammary gland hyperplasia (MGH). However, the material basis and mechanism of its efficacy are still unclear.
Results: Our results showed that in rats with MGH, polysaccharide from Prunella vulgaris L. (PVP) led to a reduction in the levels of estradiol, prolactin and malondialdehyde, while simultaneously increasing the concentrations of progesterone (P), superoxide dismutase (SOD), manganese superoxide dismutase (MnSOD) and catalase (CAT) in the serum. In addition, results obtained from 16S rRNA sequencing demonstrated that PVP had the capacity to increase the richness and diversity of the intestinal microbiota in MGH rats, as well as modify the structure of the microbiota. Correlation analysis revealed that the levels of P, SOD, MnSOD and CAT were positively associated with Allobaculum, Romboutsia, Faecalibaculum and Clostridium, while negatively correlated with Turicibacter.
Conclusions: The mechanism of PVP in treating MGH might be through inhibiting the phosphorylation of the AKT-FOXO3a signaling pathway and then activating the expression of downstream antioxidant enzymes, such as MnSOD and CAT. At the same time, PVP could restore intestinal flora homeostasis in rats with MGH by regulating the flora changes of Allobaculum, Romboutsia, Clostridium and Faecalibaculum, thereby reducing oxidative stress in rats with MGH. © 2024 Society of Chemical Industry.
(© 2024 Society of Chemical Industry.)
Databáze: MEDLINE
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