Deciphering vimentin assembly: Bridging theoretical models and experimental approaches.

Autor:	Jeong S; Department of Agricultural Biotechnology, Center for Food and Bioconversions, and Research Institute for Agriculture and Life Sciences, CALS, Seoul National University, Seoul 08826, Republic of Korea., Ha NC; Department of Agricultural Biotechnology, Center for Food and Bioconversions, and Research Institute for Agriculture and Life Sciences, CALS, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: hanc210@snu.ac.kr.
Jazyk:	angličtina
Zdroj:	Molecules and cells [Mol Cells] 2024 Jul; Vol. 47 (7), pp. 100080. Date of Electronic Publication: 2024 Jun 11.
DOI:	10.1016/j.mocell.2024.100080
Abstrakt:	The intricate assembly process of vimentin intermediate filaments (IFs), key components of the eukaryotic cytoskeleton, has yet to be elucidated. In this work, we investigated the transition from soluble tetrameric vimentin units to mature 11-nm tubular filaments, addressing a significant gap in the understanding of IF assembly. Through a combination of theoretical modeling and analysis of experimental data, we propose a novel assembly sequence, emphasizing the role of helical turns and gap filling by soluble tetramers. Our findings shed light on the unique structural dynamics of vimentin and suggest broader implications for the general principles of IF formation. Competing Interests: Declaration of Competing Interests The author is an Editorial Board Member/Editor-in-Chief/Associate Editor/Guest Editor for [Molecules and Cells] and was not involved in the editorial review or the decision to publish this article. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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