Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo.

Autor: Vakaniaki EH; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Kacita C; Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo., Kinganda-Lusamaki E; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses endémiques et émergentes), Université de Montpellier, French National Research Institute for Sustainable Development (IRD), INSERM, Montpellier, France., O'Toole Á; Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK., Wawina-Bokalanga T; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo., Mukadi-Bamuleka D; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Amuri-Aziza A; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Malyamungu-Bubala N; Kamituga General Hospital, South Kivu, Democratic Republic of the Congo., Mweshi-Kumbana F; Kamituga General Hospital, South Kivu, Democratic Republic of the Congo., Mutimbwa-Mambo L; Kamituga Health Zone, South Kivu, Democratic Republic of the Congo., Belesi-Siangoli F; Provincial Health Division, South Kivu, Democratic Republic of the Congo., Mujula Y; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Parker E; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria., Muswamba-Kayembe PC; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Nundu SS; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Lushima RS; Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo., Makangara-Cigolo JC; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo., Mulopo-Mukanya N; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Pukuta-Simbu E; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Akil-Bandali P; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Kavunga H; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo., Abdramane O; Medical Department, The Alliance for International Medical Action, Goma, Democratic Republic of the Congo., Brosius I; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Bangwen E; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Vercauteren K; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Sam-Agudu NA; Department of Pediatrics and Child Health, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.; International Research Center of Excellence, Institute of Human Virology Nigeria, Abuja, Nigeria.; Global Pediatrics Program and Division of Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA., Mills EJ; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada., Tshiani-Mbaya O; Frederick National Laboratory, Leidos Biomedical Research, Clinical Monitoring Research Program Directorate, Frederick, MD, USA., Hoff NA; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA, USA., Rimoin AW; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA, USA., Hensley LE; US Department of Agriculture, Manhattan, KS, USA., Kindrachuk J; University of Manitoba, Winnipeg, Manitoba, Canada., Baxter C; Centre for Epidemic Response and Innovation, Stellenbosch University, Cape Town, South Africa., de Oliveira T; Centre for Epidemic Response and Innovation, Stellenbosch University, Cape Town, South Africa., Ayouba A; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses endémiques et émergentes), Université de Montpellier, French National Research Institute for Sustainable Development (IRD), INSERM, Montpellier, France., Peeters M; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses endémiques et émergentes), Université de Montpellier, French National Research Institute for Sustainable Development (IRD), INSERM, Montpellier, France., Delaporte E; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses endémiques et émergentes), Université de Montpellier, French National Research Institute for Sustainable Development (IRD), INSERM, Montpellier, France., Ahuka-Mundeke S; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo., Mohr EL; Department of Pediatrics, Division of Infectious Diseases, University of Wisconsin-Madison, Madison, WI, USA., Sullivan NJ; National Emerging Infectious Diseases Laboratory, Boston University, Boston, MA, USA., Muyembe-Tamfum JJ; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo., Nachega JB; Department of Epidemiology, Infectious Diseases and Microbiology, University of Pittsburgh, School of Public Health, Pittsburgh, PA, USA. jbn16@pitt.edu.; Department of Epidemiology and International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. jbn16@pitt.edu.; Department of Medicine, Division of Infectious Diseases, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, South Africa. jbn16@pitt.edu., Rambaut A; Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK., Liesenborghs L; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium., Mbala-Kingebeni P; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo. mbalaplacide@gmail.com.; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo. mbalaplacide@gmail.com.
Jazyk: angličtina
Zdroj: Nature medicine [Nat Med] 2024 Jun 13. Date of Electronic Publication: 2024 Jun 13.
DOI: 10.1038/s41591-024-03130-3
Abstrakt: Outbreaks of monkeypox (mpox) have historically resulted from zoonotic spillover of clade I monkeypox virus (MPXV) in Central Africa and clade II MPXV in West Africa. In 2022, subclade IIb caused a global epidemic linked to transmission through sexual contact. Here we describe the epidemiological and genomic features of an mpox outbreak in a mining region in eastern Democratic Republic of the Congo, caused by clade I MPXV. Surveillance data collected between September 2023 and January 2024 identified 241 suspected cases. Genomic analysis demonstrates a distinct clade I lineage divergent from previously circulating strains in the Democratic Republic of the Congo. Of the 108 polymerase chain reaction-confirmed mpox cases, the median age of individuals was 22 years, 51.9% were female and 29% were sex workers, suggesting a potential role for sexual transmission. The predominance of APOBEC3-type mutations and the estimated emergence time around mid-September 2023 imply recent sustained human-to-human transmission.
(© 2024. The Author(s).)
Databáze: MEDLINE
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