Nutrient acquisition strategies by gut microbes.
| Autor: | Muramatsu MK; Department of Internal Medicine, Division of Infectious Diseases, UC Davis, Davis, CA 95616, USA., Winter SE; Department of Internal Medicine, Division of Infectious Diseases, UC Davis, Davis, CA 95616, USA. Electronic address: sebwinter@ucdavis.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Cell host & microbe [Cell Host Microbe] 2024 Jun 12; Vol. 32 (6), pp. 863-874. |
| DOI: | 10.1016/j.chom.2024.05.011 |
| Abstrakt: | The composition and function of the gut microbiota are intimately tied to nutrient acquisition strategies and metabolism, with significant implications for host health. Both dietary and host-intrinsic factors influence community structure and the basic modes of bacterial energy metabolism. The intestinal tract is rich in carbon and nitrogen sources; however, limited access to oxygen restricts energy-generating reactions to fermentation. By contrast, increased availability of electron acceptors during episodes of intestinal inflammation results in phylum-level changes in gut microbiota composition, suggesting that bacterial energy metabolism is a key driver of gut microbiota function. In this review article, we will illustrate diverse examples of microbial nutrient acquisition strategies in the context of habitat filters and anatomical location and the central role of energy metabolism in shaping metabolic strategies to support bacterial growth in the mammalian gut. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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