Association of Sarcopenia and Oxygen Uptake Efficiency Slope in Male Patients With Heart Failure.

Autor:	Bispo HN; Author Affiliations: Heart Institute (InCor) (Messrs Bispo and Rondon and Drs dos Santos, de Souza, da Costa, Negrão, Alves, and Fonseca), Bone Metabolism Laboratory, Rheumatology Division (Ms Pereira), University of São Paulo Medical School, São Paulo, Brazil; School of Physical Education and Sport (Drs Negrão and Fonseca), University of São Paulo, São Paulo, Brazil; and Department of Physical Education and Sport Sciences, Faculty of Education and Health Sciences, Health Research Institute (Dr Carson), University of Limerick, Limerick, Ireland., Rondon E, Dos Santos MR, de Souza FR, da Costa MJA, Pereira RMR, Negrão CE, Carson BP, Alves MNN, da Fonseca GWP
Jazyk:	angličtina
Zdroj:	Journal of cardiopulmonary rehabilitation and prevention [J Cardiopulm Rehabil Prev] 2024 Jul 01; Vol. 44 (4), pp. 273-279. Date of Electronic Publication: 2024 Jun 07.
DOI:	10.1097/HCR.0000000000000872
Abstrakt:	Purpose: Sarcopenia, the loss of muscle mass and function, is a common comorbidity in patients with heart failure (HF). The skeletal muscle modulates the respiratory response during exercise. However, whether ventilatory behavior is affected by sarcopenia is still unknown. Methods: We enrolled 169 male patients with HF. Muscle strength was measured by a handgrip dynamometer. Body composition was measured with dual-energy X-ray absorptiometry. Sarcopenia was defined by handgrip strength <27 kg and appendicular lean mass divided by height squared (ALM/height 2 ) <7.0 kg/m 2 . Oxygen uptake efficiency slope (OUES), ventilation (VE), oxygen uptake (VO 2 ), and carbon dioxide output (VCO 2 ) were measured by a cardiopulmonary exercise test. Results: Sarcopenia was identified in 29 patients (17%). At the first ventilatory threshold, VE/VO 2 (36.9 ± 5.9 vs 32.7 ± 6.5; P = .003) and VE/VCO 2 (39.8 ± 7.2 vs 35.3 ± 6.9; P = .004) were higher in patients with sarcopenia compared to those without sarcopenia. At the exercise peak, compared to patients without sarcopenia, patients with sarcopenia had lower OUES (1186 ± 295 vs 1634 ± 564; P < .001), relative VO 2 (16.2 ± 5.0 vs 19.5 ± 6.5 mL/kg/min; P = .01), and VE (47.3 ± 10.1 vs 63.0 ± 18.2 L/min; P < .0001), while VE/VCO 2 (42.9 ± 8.9 vs 38.7 ± 8.4; P = .025) was increased. OUES was positively correlated with ALM/height 2 ( r = 0.36; P < .0001) and handgrip strength ( r = 0.31; P < .001). Hemoglobin (OR = 1.149; 95% CI, 0.842-1.570; P = .038), ALM/height 2 (OR = 2.166; 95% CI, 1.338-3.504; P = .002), and VO 2peak (OR = 1.377; 95% CI, 1.218-1.557; P < .001) were independently associated with OUES adjusted by cofounders. Conclusions: Our results suggest that sarcopenia is related to impaired ventilatory response during exercise in patients with HF. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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