Survival Analysis and Immune Differences of HIV Long-Term Non-progressors in Xinjiang China: A 12-Year Prospective Cohort Observation.

Autor: Li Y; Public Health School, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China., Ni Y; Public Health School, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China., He Q; Public Health School, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China., Hu X; STD/HIV Prevention and Control Center, Xinjiang Uighur Autonomous Region Center for Disease Control and Prevention, Urumqi, 830002, Xinjiang, China., Zhang Y; HIV/STD Prevention and Control, Yining City Center for Disease Control and Prevention, Ili Kazakh Autonomous Prefecture, 835000, Xinjiang, China., He X; Laboratory, Yining Second People's Hospital (Jinling Sunshine Hospital), Ili Kazakh Autonomous Prefecture, 835000, Xinjiang, China., Ni M; STD/HIV Prevention and Control Center, Xinjiang Uighur Autonomous Region Center for Disease Control and Prevention, Urumqi, 830002, Xinjiang, China. xjnmj@126.com.
Jazyk: angličtina
Zdroj: AIDS and behavior [AIDS Behav] 2024 Sep; Vol. 28 (9), pp. 3151-3160. Date of Electronic Publication: 2024 Jun 13.
DOI: 10.1007/s10461-024-04396-x
Abstrakt: This 12-year cohort study of 80 long-term non-progressors (LTNPs) observed a cumulative follow-up duration of 628.5 person-years. Among them, 60 received antiretroviral therapy (ART) for a total of 418.6 person-years. Twenty-four deaths occurred during the follow-up period, with an average age of 42.36 years and a lowest 8-year survival rate of 0.90. Cox model analysis revealed that the risk of AIDS-related death was 1.47 times higher for non-marital, non-commercial heterosexual transmission than for injection drug use. Treatment initiation at ages 31-40 was correlated with an elevated risk of mortality, while treatment for 3-10 years reduced mortality risks in untreated LTNPs. Flow cytometry observed significant differences in the proportion of NK cells. Long-term ART (> 2 years) before LTNPs developed AIDS symptoms could lower mortality risk and potentially extend lifespan, especially when it was initiated at a younger age without affecting NK cell balance. Epidemiological and immunological studies on ART-treated LTNPs are vital for advancing HIV treatment and achieving functional cures for AIDS individuals.
(© 2024. The Author(s).)
Databáze: MEDLINE
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