A Model for the Coexistence of Competing Mechanisms for Ca 2 + Oscillations in T-lymphocytes.

Autor: Castaneda Ruan P; Department of Mathematics, University of Auckland, Auckland Central, 1142, Auckland, New Zealand. paco.castaneda.ruan@auckland.ac.nz., Benson JC; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 1526, USA.; Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 1526, USA.; Graduate Program in Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, 17033, USA., Trebak M; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 1526, USA.; Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 1526, USA., Kirk V; Department of Mathematics, University of Auckland, Auckland Central, 1142, Auckland, New Zealand., Sneyd J; Department of Mathematics, University of Auckland, Auckland Central, 1142, Auckland, New Zealand.
Jazyk: angličtina
Zdroj: Bulletin of mathematical biology [Bull Math Biol] 2024 Jun 13; Vol. 86 (7), pp. 86. Date of Electronic Publication: 2024 Jun 13.
DOI: 10.1007/s11538-024-01317-w
Abstrakt: Ca 2 + is a ubiquitous signaling mechanism across different cell types. In T-cells, it is associated with cytokine production and immune function. Benson et al. have shown the coexistence of competing Ca 2 + oscillations during antigen stimulation of T-cell receptors, depending on the presence of extracellular Ca 2 + influx through the Ca 2 + release-activated Ca 2 + channel (Benson in J Biol Chem 29:105310, 2023). In this paper, we construct a mathematical model consisting of five ordinary differential equations and analyze the relationship between the competing oscillatory mechanisms.. We perform bifurcation analysis on two versions of our model, corresponding to the two oscillatory types, to find the defining characteristics of these two families.
(© 2024. The Author(s).)
Databáze: MEDLINE
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