Preparation and Characterization of Chitosan Nanofiber: Kinetic Studies and Enhancement of Insulin Delivery System.

Autor:	Fouad SA; Chemistry Department, Faculty of Science, Alexandria University, Ibrahimia, Alexandria 21321, Egypt., Ismail AM; Chemistry Department, Faculty of Science, Alexandria University, Ibrahimia, Alexandria 21321, Egypt., Abdel Rafea M; Department of Physics, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia., Abu Saied MA; Polymeric Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications (SRTA-CITY), New Borg El-Arab, Alexandria 21934, Egypt., El-Dissouky A; Chemistry Department, Faculty of Science, Alexandria University, Ibrahimia, Alexandria 21321, Egypt.
Jazyk:	angličtina
Zdroj:	Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2024 May 29; Vol. 14 (11). Date of Electronic Publication: 2024 May 29.
DOI:	10.3390/nano14110952
Abstrakt:	Insulin-loaded nanofibers were prepared using chitosan as a natural polymer. The loaded insulin with polyethylene oxide was used for preparing monolayer batch S1. Nanofiber S1 was coated by seven layers of film on both sides to form batch S2 as a sandwich containing Layer A (CS, PEG and PEO) and Layer B (PEG and PEO) using electrospinning apparatus. SEM, TEM and FT-IR techniques were used to confirm the drug loading within the composite nanofibers. The in vitro activity that provided a sustained and controlled release of the drug from the nanofiber batch was studied at different pH values spectrophotometrically using a dialysis method. In batches S1 and S2, the release of insulin from nanofiber proceeds via burst release necessary to produce the desired therapeutic activity, followed by slow step. The rate and the percentage release of insulin in batch S2 are found to be higher at all pH values.
Databáze:	MEDLINE
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