| Autor: |
Thomas RG; Department of Radiology, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea., Kim S; Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501190, Republic of Korea., Tran TA; Biomedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun 58128, Republic of Korea.; Brain Tumor Research Laboratory, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea., Kim YH; Brain Tumor Research Laboratory, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea., Nagareddy R; Department of Radiology, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea., Jung TY; Brain Tumor Research Laboratory, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea.; Department of Neurosurgery, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea., Kim SK; Department of Radiology, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea.; Department of Radiology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea., Jeong YY; Department of Radiology, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea.; Department of Radiology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea. |
| Abstrakt: |
Background. The aim of the study was to synthesize liposomal nanoparticles loaded with temozolomide and ferucarbotran (LTF) and to evaluate the theranostic effect of LTF in the glioma model. Methods. We synthesized an LTF that could pass through the Blood Brain Barrier (BBB) and localize in brain tumor tissue with the help of magnet guidance. We examined the chemical characteristics. Cellular uptake and cytotoxicity studies were conducted in vitro. A biodistribution and tumor inhibition study was conduted using an in vivo glioma model. Results. The particle size and surface charge of LTF show 108 nm and -38 mV, respectively. Additionally, the presence of ferucarbotran significantly increased the contrast agent effect of glioma compared to the control group in MR imaging. Magnet-guided LTF significantly reduced the tumor size compared to control and other groups. Furthermore, compared to the control group, our results demonstrate a significant inhibition in brain tumor size and an increase in lifespan. Conclusions. These findings suggest that the LTF with magnetic guidance represents a novel approach to address current obstacles, such as BBB penetration of nanoparticles and drug resistance. Magnet-guided LTF is able to enhance therapeutic efficacy in mouse brain glioma. |
