Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.

Autor:	Ni Z; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland., Kundu P; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., McKean DF; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland., Wheeler W; Information Management Systems, Silver Spring, Maryland., Albanes D; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Andreotti G; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Antwi SO; Department of Quantitative Health Sciences Research, Mayo Clinic College of Medicine, Jacksonville, Florida., Arslan AA; Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York.; Department of Population Health, New York University School of Medicine, New York, New York.; Department of Environmental Medicine, New York University School of Medicine, New York, New York., Bamlet WR; Department of Quantitative Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota., Beane-Freeman LE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Bracci PM; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California., Brennan P; International Agency for Research on Cancer, Lyon, France., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Gallinger S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Canada., Gaziano JM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts.; Division of Aging, Brigham and Women's Hospital, Boston, Massachusetts.; Boston VA Healthcare System, Boston, Massachusetts., Giles GG; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia., Giovannucci EL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Goggins MG; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland., Goodman PJ; SWOG Statistical Center, Fred Hutchinson Cancer Center, Seattle, Washington., Haiman CA; Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California., Hassan MM; Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Holly EA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California., Hung RJ; Lunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Canada., Katzke V; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington., Kraft P; Trans-Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., LeMarchand L; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii., Li D; Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., McCullough ML; Department of Population Science, American Cancer Society, Atlanta, Georgia., Milne RL; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia., Moore SC; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Neale RE; Department of Population Health, QIMR Berghofer Medical Research Institute, Queensland, Australia., Oberg AL; Department of Quantitative Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota., Patel AV; Department of Population Science, American Cancer Society, Atlanta, Georgia., Peters U; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., Rabe KG; Department of Quantitative Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota., Risch HA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Smith-Byrne K; Cancer Epidemiology Unit, The Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom., Visvanathan K; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Wactawski-Wende J; Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York., White E; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Department of Epidemiology, University of Washington, Seattle, Washington., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Yu H; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii., Zeleniuch-Jacquotte A; Department of Population Health, New York University School of Medicine, New York, New York.; Perlmutter Cancer Center, New York University School of Medicine, New York, New York., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee., Zhong J; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Amundadottir LT; Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Stolzenberg-Solomon RZ; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Klein AP; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland.; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2024 Sep 03; Vol. 33 (9), pp. 1229-1239.
DOI:	10.1158/1055-9965.EPI-24-0096
Abstrakt:	Background: Pancreatic cancer is a leading cause of cancer-related death globally. Risk factors for pancreatic cancer include common genetic variants and potentially heavy alcohol consumption. We assessed if genetic variants modify the association between heavy alcohol consumption and pancreatic cancer risk. Methods: We conducted a genome-wide interaction analysis of single-nucleotide polymorphisms (SNP) by heavy alcohol consumption (more than three drinks per day) for pancreatic cancer in European ancestry populations from genome-wide association studies. Our analysis included 3,707 cases and 4,167 controls from case-control studies and 1,098 cases and 1,162 controls from cohort studies. Fixed-effect meta-analyses were conducted. Results: A potential novel region of association on 10p11.22, lead SNP rs7898449 (interaction P value (Pinteraction) = 5.1 × 10-8 in the meta-analysis; Pinteraction = 2.1 × 10-9 in the case-control studies; Pinteraction = 0.91 in the cohort studies), was identified. An SNP correlated with this lead SNP is an expression quantitative trait locus for the neuropilin 1 gene. Of the 17 genomic regions with genome-wide significant evidence of association with pancreatic cancer in prior studies, we observed suggestive evidence that heavy alcohol consumption modified the association for one SNP near LINC00673, rs11655237 on 17q25.1 (Pinteraction = 0.004). Conclusions: We identified a novel genomic region that may be associated with pancreatic cancer risk in conjunction with heavy alcohol consumption located near an expression quantitative trait locus for neuropilin 1, a protein that plays an important role in the development and progression of pancreatic cancer. Impact: This work can provide insights into the etiology of pancreatic cancer, particularly in heavy drinkers. (©2024 American Association for Cancer Research.)
Databáze:	MEDLINE
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