Long-term in vivo dissolution of thermo- and pH-responsive, 19 F magnetic resonance-traceable and injectable polymer implants.

Autor:	Jirát-Ziółkowska N; Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine Videnska 1958/9 140 21 Prague Czech Republic daniel.jirak@ikem.cz +420-736467349.; Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University Katerinska 1660/32 Prague 121 08 Czech Republic., Vít M; Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine Videnska 1958/9 140 21 Prague Czech Republic daniel.jirak@ikem.cz +420-736467349., Groborz O; Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University Katerinska 1660/32 Prague 121 08 Czech Republic.; Institute of Macromolecular Chemistry, Czech Academy of Sciences Heyrovsky square 2 162 06 Prague Czech Republic., Kolouchová K; Institute of Macromolecular Chemistry, Czech Academy of Sciences Heyrovsky square 2 162 06 Prague Czech Republic., Červený D; Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine Videnska 1958/9 140 21 Prague Czech Republic daniel.jirak@ikem.cz +420-736467349.; Faculty of Health Studies, Technical University of Liberec Studentska 1402/2 Liberec 461 17 Czech Republic., Sedláček O; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University Hlavova 8 Prague 128 00 Czech Republic., Jirák D; Radiodiagnostic and Interventional Radiology Department, Institute for Clinical and Experimental Medicine Videnska 1958/9 140 21 Prague Czech Republic daniel.jirak@ikem.cz +420-736467349.; Faculty of Health Studies, Technical University of Liberec Studentska 1402/2 Liberec 461 17 Czech Republic.
Jazyk:	angličtina
Zdroj:	Nanoscale advances [Nanoscale Adv] 2024 Apr 08; Vol. 6 (12), pp. 3041-3051. Date of Electronic Publication: 2024 Apr 08 (Print Publication: 2024).
DOI:	10.1039/d4na00212a
Abstrakt:	19 F magnetic resonance ( 19 F MR) tracers stand out for their wide range of applications in experimental and clinical medicine, as they can be precisely located in living tissues with negligible fluorine background. This contribution demonstrates the long-term dissolution of multiresponsive fluorinated implants designed for prolonged release. Implants were detected for 14 (intramuscular injection) and 20 (subcutaneous injection) months by 19 F MR at 4.7 T, showing favorable MR relaxation times, biochemical stability, biological compatibility and slow, long-term dissolution. Thus, polymeric implants may become a platform for long-term local theranostics. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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