Ayahuasca: A review of historical, pharmacological, and therapeutic aspects.

Autor: Ruffell SGD; Onaya Science Iquitos Peru.; Psychae Institute Melbourne Victoria Australia.; School of Population and Global Health University of Melbourne Melbourne Australia., Crosland-Wood M; Onaya Science Iquitos Peru.; Psychology and Psychotherapy department Central and North West London NHS Trust London UK., Palmer R; Onaya Science Iquitos Peru.; School of Medicine University of Yale New Haven Connecticut USA.; Department of Psychology University of New Mexico Albuquerque New Mexico USA., Netzband N; Onaya Science Iquitos Peru., Tsang W; Onaya Science Iquitos Peru.; Institute of Psychology, Psychiatry and Neuroscience South London and The Maudsley NHS Trust London UK.; Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience King's College London London UK., Weiss B; Onaya Science Iquitos Peru.; Division of Psychiatry Imperial College London London UK., Gandy S; Onaya Science Iquitos Peru., Cowley-Court T; Psychae Institute Melbourne Victoria Australia.; School of Population and Global Health University of Melbourne Melbourne Australia., Halman A; School of Population and Global Health University of Melbourne Melbourne Australia., McHerron D; Psychae Institute Melbourne Victoria Australia., Jong A; Institute of Psychology, Psychiatry and Neuroscience South London and The Maudsley NHS Trust London UK.; Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience King's College London London UK., Kennedy T; Psychae Institute Melbourne Victoria Australia., White E; Psychae Institute Melbourne Victoria Australia., Perkins D; Psychae Institute Melbourne Victoria Australia.; School of Population and Global Health University of Melbourne Melbourne Australia.; Centre for Mental Health Swinburne University Melbourne Australia., Terhune DB; Psychology and Psychotherapy department Central and North West London NHS Trust London UK., Sarris J; Psychae Institute Melbourne Victoria Australia.; NICM Health Research Institute Western Sydney University Sydney Australia.; Florey Institute for Neuroscience and Mental Health University of Melbourne Melbourne Australia.
Jazyk: angličtina
Zdroj: PCN reports : psychiatry and clinical neurosciences [PCN Rep] 2023 Oct 02; Vol. 2 (4), pp. e146. Date of Electronic Publication: 2023 Oct 02 (Print Publication: 2023).
DOI: 10.1002/pcn5.146
Abstrakt: Ayahuasca is a psychedelic plant brew originating from the Amazon rainforest. It is formed from two basic components, the Banisteriopsis caapi vine and a plant containing the potent psychedelic dimethyltryptamine (DMT), usually Psychotria viridis . Here we review the history of ayahuasca and describe recent work on its pharmacology, phenomenological responses, and clinical applications. There has been a significant increase in interest in ayahuasca since the turn of the millennium. Anecdotal evidence varies significantly, ranging from evangelical accounts to horror stories involving physical and psychological harm. The effects of the brew on personality and mental health outcomes are discussed in this review. Furthermore, phenomenological analyses of the ayahuasca experience are explored. Ayahuasca is a promising psychedelic agent that warrants greater empirical attention regarding its basic neurochemical mechanisms of action and potential therapeutic application.
Competing Interests: Simon G. D. Ruffell, Nige Netzband, and WaiFung Tsang are directors of a not‐for‐profit research institute. Jerome Sarris and Daniel Perkins are directors of a not‐for‐profit medicinal psychedelics research institute. Simon G. D. Ruffell, Tessa Cowley‐Court, and Diana McHerron are employed at this not‐for‐profit medicinal psychedelics research institute. Jerome Sarris is supported by an National Health and Medical Research Council (NHMRC) Clinical (Fellowship APP1125000).
(© 2023 The authors. Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.)
Databáze: MEDLINE
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