The co-occurrence of antibiotic resistance genes between dogs and their owners in families.

Autor:	Zhao R; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou Guangdong China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China., Hao J; Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou Guangdong China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China., Yang J; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China., Tong C; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou Guangdong China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China., Xie L; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou Guangdong China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China., Xiao D; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou Guangdong China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China., Zeng Z; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou Guangdong China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China., Xiong W; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou Guangdong China.; National Laboratory of Safety Evaluation (Environmental Assessment) of Veterinary Drugs, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine South China Agricultural University Guangzhou Guangdong China.
Jazyk:	angličtina
Zdroj:	IMeta [Imeta] 2022 May 04; Vol. 1 (2), pp. e21. Date of Electronic Publication: 2022 May 04 (Print Publication: 2022).
DOI:	10.1002/imt2.21
Abstrakt:	The intimate relationship between humans and companion animals causes a unique and critical aspect of antimicrobial resistance in humans. However, a comprehensive analysis of antimicrobial resistance between companion animals and their owners is lacking. Here, we chose 13 owned dogs and 16 owners as well as 22 kennel dogs to analyze the effect of an intimate relationship between owned dogs and owners on their gut microbiome, antibiotic resistance genes (ARGs), and mobile genetic elements (MGEs) and study the correlation of antimicrobial resistance between dogs and their owners in families by metagenomics. Dog gut microbiota had a higher abundance and diversity of ARGs while owners had a higher diversity of taxonomy. In the owned dog gut microbial community, ARG and MGE compositions were significantly more similar to the owner's gut microbiota than those of others. From the perspective of families, there was a strong correlation between macrolide resistance genes between dogs and their owners. In conclusion, our study demonstrated the correlation of ARGs between dogs and their owners at a community-wide level. These findings can alarm the use of antibiotics in companion animals, which implies the potential to harbor antimicrobial resistance and threaten public health. Competing Interests: The authors declare no conflicts of interest. (© 2022 The Authors. iMeta published by John Wiley & Sons Australia, Ltd on behalf of iMeta Science.)
Databáze:	MEDLINE
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