Left anterior descending coronary artery-left circumflex coronary artery bifurcation angle and severity of coronary artery disease; is there any correlation? A cross-sectional study.

Autor: Mansouri P; Tehran Heart Center, Cardiovascular Disease Research Institute Tehran University of Medical Sciences Tehran Iran., Nematipour E; Tehran Heart Center, Cardiovascular Disease Research Institute Tehran University of Medical Sciences Tehran Iran., Rajablou N; School of Medicine Tehran University of Medical Sciences Tehran Iran., Ghorashi SM; Tehran Heart Center, Cardiovascular Disease Research Institute Tehran University of Medical Sciences Tehran Iran., Azari S; Hospital Management Research Center, Health Management Research Institute Iran University of Medical Sciences Tehran Iran.; Research Center for Emergency and Disaster Resilience Red Crescent Society of the Islamic Republic of Iran Tehran Iran., Omidi N; Cardiovascular Imaging Departement, Tehran Heart Center, School of Medicin, Tehran University of Medical Sciences Tehran heart center Tehran Iran.; Cardiac Primary Prevention Research Center, Cardiovascular Institute, Tehran University of Medical Science Tehran heart center Tehran Iran.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2024 Jun 12; Vol. 7 (6), pp. e2182. Date of Electronic Publication: 2024 Jun 12 (Print Publication: 2024).
DOI: 10.1002/hsr2.2182
Abstrakt: Background and Aims: The aim of this study is to evaluate the association of coronary computed tomography angiography derived (CCTA) plaque characteristics and the left anterior descending coronary artery (LAD) and left circumflex coronary artery (LCX) bifurcation angle with severity of coronary artery disease (CAD).
Methods: All the stable patients with suspected CAD who underwent CCTA between January to December 2021 were included. Correlation between CCTA-derived aggregated plaque volume (APV), LAD-LCX angle, remodeling index (RI), coronary calcium score with Gensini score in conventional angiography were assessed. One hundred and twenty-two patients who underwent both CCTA and coronary angiography were analyzed.
Results: Our analysis showed that the median (percentile 25% to percentile 75%) of the APV, LAD-LCx angle, and calcium score were 31% (17%-47%), 58° (39°-89°), and 31 (0-186), respectively. Also, the mean ± SD of the RI was 1.05 ± 0.20. Significant correlation between LAD-LCx bifurcation angle (0.0001-0.684), APV (0.002-0.281), RI (0.0001-0.438), and calcium score (0.016-0.217) with Gensini score were detected. There was a linear correlation between the mean LAD-LCx bifurcation angle and the Gensini score. The sensitivity and specificity for the cut-off value of 47.5° for the LAD-LCX angle were 86.7% and 82.1%, respectively.
Conclusion: There is a direct correlation between the LAD-LCx angle and the Gensini score. In addition to plaque characteristics, anatomic-based CCTA-derived indices can be used to identify patients at higher risk for CAD.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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