Reduced gamma oscillation during visual processing of the mother's face in children with autism spectrum disorder: A pilot study.

Autor: Hasegawa C; Research Center for Child Mental Development Kanazawa University Kanazawa Japan.; Japan Society for the Promotion of Science Chiyoda-ku Tokyo Japan.; School of Psychological Sciences Macquarie University Sydney Australia., Ikeda T; Research Center for Child Mental Development Kanazawa University Kanazawa Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine Chiba University, and University of Fukui Osaka/Kanazawa/Hamamatsu/Chiba/Fukui Japan.; University of Fukui Fukui Japan., Yoshimura Y; Research Center for Child Mental Development Kanazawa University Kanazawa Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine Chiba University, and University of Fukui Osaka/Kanazawa/Hamamatsu/Chiba/Fukui Japan.; Institute of Human and Social Sciences Kanazawa University Kanazawa Japan., Kumazaki H; Department of Future Psychiatric Medicine, Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan., Saito DN; Research Center for Child Mental Development Kanazawa University Kanazawa Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine Chiba University, and University of Fukui Osaka/Kanazawa/Hamamatsu/Chiba/Fukui Japan.; Department of Psychology, Faculty of Psychology Yasuda Woman's University Hiroshima Japan., Yaoi K; Research Center for Child Mental Development Kanazawa University Kanazawa Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine Chiba University, and University of Fukui Osaka/Kanazawa/Hamamatsu/Chiba/Fukui Japan., An KM; Research Center for Child Mental Development Kanazawa University Kanazawa Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine Chiba University, and University of Fukui Osaka/Kanazawa/Hamamatsu/Chiba/Fukui Japan.; School of Psychology University of Birmingham Birmingham UK.; Centre for Human Brain Health, School of Psychology University of Birmingham Birmingham UK., Takahashi T; Research Center for Child Mental Development Kanazawa University Kanazawa Japan.; Uozu Shinkei Sanatorium Uozu Japan.; Department of Neuropsychiatry University of Fukui Fukui Japan., Hirata M; Department of Neurological Diagnosis and Restoration, Graduate School of Medicine Osaka University Suita Japan.; Department of Neurosurgery Osaka University Medical School Suita Japan.; Center for Information and Neural Networks National Institute of Information and Communications Technology Suita Japan.; Open and Transdisciplinary Research Initiatives, Symbiotic Intelligent System Research Center Osaka University Suita Japan., Asada M; Center for Information and Neural Networks National Institute of Information and Communications Technology Suita Japan.; Open and Transdisciplinary Research Initiatives, Symbiotic Intelligent System Research Center Osaka University Suita Japan.; International Professional University of Technology in Osaka Osaka Japan.; Chubu University Academy of Emerging Sciences Kasugai Japan., Kikuchi M; Research Center for Child Mental Development Kanazawa University Kanazawa Japan.; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine Chiba University, and University of Fukui Osaka/Kanazawa/Hamamatsu/Chiba/Fukui Japan.; Department of Psychiatry and Neurobiology Kanazawa University Kanazawa Japan.
Jazyk: angličtina
Zdroj: PCN reports : psychiatry and clinical neurosciences [PCN Rep] 2023 Jan 26; Vol. 2 (1), pp. e68. Date of Electronic Publication: 2023 Jan 26 (Print Publication: 2023).
DOI: 10.1002/pcn5.68
Abstrakt: Aim: This study aimed to investigate gamma oscillations related to face processing of children with autism spectrum disorders and typically developed children using magnetoencephalography.
Methods: We developed stimuli that included naturalistic real-time eye-gaze situations between participants and their mothers. Eighteen young children with autism spectrum disorders (62-97 months) and 24 typically developed children (61-79 months) were included. The magnetoencephalography data were analyzed in the bilateral banks of the superior temporal sulcus, fusiform gyrus, and pericalcarine cortex for frequency ranges 30-59 and 61-90 Hz. The gamma oscillation normalized values were calculated to compare the face condition (children gazing at mother's face) and control measurements (baseline) using the following formula: (face - control)/(face + control).
Results: The results revealed significant differences in gamma oscillation normalized values in the low gamma band (30-59 Hz) in the right banks of the superior temporal sulcus, right fusiform gyrus, and right pericalcarine cortex between children with autism spectrum disorders and typically developed children. Furthermore, there were significant differences in gamma oscillation normalized values in the high gamma band (61-90 Hz) in the right banks of the superior temporal sulcus, bilateral fusiform gyrus, and bilateral pericalcarine cortex between the groups.
Conclusion: This report is the first magnetoencephalography study revealing atypical face processing in young children with autism spectrum disorders using relevant stimuli between participants and their mothers. Our naturalistic paradigm provides a useful assessment of social communication traits and a valuable insight into the underlying neural mechanisms in children with autism spectrum disorders.
Competing Interests: The authors declare that the research was conducted without any commercial or financial relationships that could be construed as potential competing or conflicts of interest.
(© 2023 The Authors. Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.)
Databáze: MEDLINE
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