Antibody signatures against viruses and microbiome reflect past and chronic exposures and associate with aging and inflammation.

Autor:	Andreu-Sánchez S; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ripoll-Cladellas A; Life Sciences Department, Barcelona Supercomputing Center, 08034 Barcelona, Catalonia, Spain., Culinscaia A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Bulut O; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboudumc, Nijmegen, the Netherlands., Bourgonje AR; Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboudumc, Nijmegen, the Netherlands.; Department for Immunology & Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany., Lansdorp P; Terry Fox Laboratory, British Columbia Cancer Research Center, Vancouver, BC, Canada.; Departments of Hematology and Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Aubert G; Terry Fox Laboratory, British Columbia Cancer Research Center, Vancouver, BC, Canada.; Repeat Diagnostics Inc, Vancouver, BC, Canada., Bonder MJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Vogl T; Center for Cancer Research, Medical University of Vienna, Wien, Austria., van der Wijst MGP; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Melé M; Life Sciences Department, Barcelona Supercomputing Center, 08034 Barcelona, Catalonia, Spain., Van Baarle D; Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Fu J; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zhernakova A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 May 16; Vol. 27 (6), pp. 109981. Date of Electronic Publication: 2024 May 16 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.109981
Abstrakt:	Encounters with pathogens and other molecules can imprint long-lasting effects on our immune system, influencing future physiological outcomes. Given the wide range of microbes to which humans are exposed, their collective impact on health is not fully understood. To explore relations between exposures and biological aging and inflammation, we profiled an antibody-binding repertoire against 2,815 microbial, viral, and environmental peptides in a population cohort of 1,443 participants. Utilizing antibody-binding as a proxy for past exposures, we investigated their impact on biological aging, cell composition, and inflammation. Immune response against cytomegalovirus (CMV), rhinovirus, and gut bacteria relates with telomere length. Single-cell expression measurements identified an effect of CMV infection on the transcriptional landscape of subpopulations of CD8 and CD4 T-cells. This examination of the relationship between microbial exposures and biological aging and inflammation highlights a role for chronic infections (CMV and Epstein-Barr virus) and common pathogens (rhinoviruses and adenovirus C). Competing Interests: P.L. is a founding shareholder in Repeat Diagnostics, a CLIA certified company specializing in leukocyte telomere length measurements using Flow-FISH, where G.A. is also employed. The other authors declare no competing interests. (© 2024 The Authors.)
Databáze:	MEDLINE
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