Stretchable ionic-electronic bilayer hydrogel electronics enable in situ detection of solid-state epidermal biomarkers.

Autor: Arwani RT; Department of Biomedical Engineering (BME), National University of Singapore, Singapore, Singapore.; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; The N.1 Institute for Health, National University of Singapore, Singapore, Singapore.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, Singapore., Tan SCL; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Sundarapandi A; Department of Biomedical Engineering (BME), National University of Singapore, Singapore, Singapore.; The N.1 Institute for Health, National University of Singapore, Singapore, Singapore.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, Singapore., Goh WP; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Liu Y; Institute of High-Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Leong FY; Institute of High-Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yang W; Department of Biomedical Engineering (BME), National University of Singapore, Singapore, Singapore.; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai, P. R. China., Zheng XT; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yu Y; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Jiang C; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ang YC; Department of Biomedical Engineering (BME), National University of Singapore, Singapore, Singapore., Kong L; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, Singapore, Singapore., Teo SL; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chen P; School of Chemistry, Chemical Engineering and Biotechnology (CCEB), Nanyang Technological University, Singapore, Singapore.; Institute for Digital Molecular Analytics and Science (IDMxS), Nanyang Technological University, Singapore, Singapore., Su X; Department of Ophthalmology, Yong Loo Lin School of Medicine, Singapore, Singapore.; Institute of Molecular Cell and Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Li H; Institute of High-Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Liu Z; Institute of High-Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chen X; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Innovative Center for Flexible Devices (iFLEX), Max Planck-NTU Joint Laboratory for Artificial Senses, School of Materials Science and Engineering (MSE), Nanyang Technological University, Singapore, Singapore., Yang L; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. yang_le@imre.a-star.edu.sg.; Department of Materials Science and Engineering (MSE), National University of Singapore, Singapore, Singapore. yang_le@imre.a-star.edu.sg., Liu Y; Department of Biomedical Engineering (BME), National University of Singapore, Singapore, Singapore. lyx@nus.edu.sg.; Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. lyx@nus.edu.sg.; The N.1 Institute for Health, National University of Singapore, Singapore, Singapore. lyx@nus.edu.sg.; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore, Singapore. lyx@nus.edu.sg.
Jazyk: angličtina
Zdroj: Nature materials [Nat Mater] 2024 Aug; Vol. 23 (8), pp. 1115-1122. Date of Electronic Publication: 2024 Jun 12.
DOI: 10.1038/s41563-024-01918-9
Abstrakt: Continuous and in situ detection of biomarkers in biofluids (for example, sweat) can provide critical health data but is limited by biofluid accessibility. Here we report a sensor design that enables in situ detection of solid-state biomarkers ubiquitously present on human skin. We deploy an ionic-electronic bilayer hydrogel to facilitate the sequential dissolution, diffusion and electrochemical reaction of solid-state analytes. We demonstrate continuous monitoring of water-soluble analytes (for example, solid lactate) and water-insoluble analytes (for example, solid cholesterol) with ultralow detection limits of 0.51 and 0.26 nmol cm -2 , respectively. Additionally, the bilayer hydrogel electrochemical interface reduces motion artefacts by a factor of three compared with conventional liquid-sensing electrochemical interfaces. In a clinical study, solid-state epidermal biomarkers measured by our stretchable wearable sensors showed a high correlation with biomarkers in human blood and dynamically correlated with physiological activities. These results present routes to universal platforms for biomarker monitoring without the need for biofluid acquisition.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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