Vitamin D deficiency as a risk factor for sudden cardiac arrest: A multicenter case-control study.

Autor: Lee MJ; Department of Emergency Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea., Jung H; Department of Emergency Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea. Electronic address: haewon@knu.ac.kr., Shin SD; Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, South Korea., Ro YS; Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, South Korea., Park JH; Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, South Korea., Roh YI; Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea., Jung WJ; Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea., Park JO; Department of Emergency Medicine, Hallym University College of Medicine, Dongtan Sacred Heart Hospital, Hwaseong, South Korea., Park SM; Department of Emergency Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea., Kim SC; Department of Emergency Medicine, Chungbuk National University College of Medicine, Cheongju, South Korea., Shin J; Department of Emergency Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea., Kim YW; Department of Emergency Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, South Korea., Hong JY; Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, South Korea., Ryu HH; Department of Emergency Medicine, Chonnam National University College of Medicine, Gwangju, South Korea., Kim SJ; Department of Emergency Medicine, Korea University College of Medicine, Seoul, South Korea., Park JH; Department of Emergency Medicine, Korea University College of Medicine, Seoul, South Korea., Kim WY; Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea., Lee GT; Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, South Korea., Oh SB; Department of Emergency Medicine, Dankook University College of Medicine, Seoul, South Korea.
Jazyk: angličtina
Zdroj: Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2024 Sep; Vol. 34 (9), pp. 2182-2189. Date of Electronic Publication: 2024 May 10.
DOI: 10.1016/j.numecd.2024.05.007
Abstrakt: Background and Aims: Vitamin D is known to influence the risk of cardiovascular disease, which is a recognized risk factor for sudden cardiac arrest (SCA). However, the relationship between vitamin D and SCA is not well understood. Therefore, this study aims to investigate the association between vitamin D and SCA in out-of-hospital cardiac arrest (OHCA) patients compared to healthy controls.
Methods and Results: Using the Phase II Cardiac Arrest Pursuit Trial with Unique Registration and Epidemiologic Surveillance (CAPTURES II) registry, a 1:1 propensity score-matched case-control study was conducted between 2017 and 2020. Serum 25-hydroxyvitamin D (vitamin D) levels in patients with OHCA (454 cases) and healthy controls (454 cases) were compared after matching for age, sex, cardiovascular risk factors, and lifestyle behaviors. The mean vitamin D levels were 14.5 ± 7.6 and 21.3 ± 8.3 ng/mL among SCA cases and controls, respectively. Logistic regression analysis was used adjusting for cardiovascular risk factors, lifestyle behaviors, corrected serum calcium levels, and estimated glomerular filtration rate (eGRF). The adjusted odds ratio (aOR) for vitamin D was 0.89 (95% confidence interval [CI] 0.87-0.91). The dose-response relationship demonstrated that vitamin D deficiency was associated with SCA incidence (severe deficiency, aOR 10.87, 95% CI 4.82-24.54; moderate deficiency, aOR 2.24, 95% CI 1.20-4.20).
Conclusion: Vitamin D deficiency was independently and strongly associated with an increased risk of SCA, irrespective of cardiovascular and lifestyle factors, corrected calcium levels, and eGFR.
(Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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