Opportunistic population screening as a hepatitis elimination strategy: the CRIVALVIR-FOCUS program.

Autor:	Ortega González E; Fundación de Investigación Hospital General Universitario de Valencia. Universidad de Valencia. Valencia, Spain., Ocete Mochón MD; Servicio de Microbiología del Hospital General Universitario de Valencia. Universidad de Valencia. Valencia, Spain., Gimeno Cardona C; Servicio de Microbiología del Hospital General Universitario de Valencia. Universidad de Valencia. Valencia, Spain., Martínez-Roma M; Fundación de Investigación Hospital General Universitario de Valencia. Universidad de Valencia. Valencia, Spain., Diago Madrid M; Servicio de Patología Digestiva del Hospital General Universitario de Valencia. Universidad de Valencia. Valencia, Spain., Gómez Muñoz N; Fundación de Investigación Hospital General Universitario de Valencia. Universidad de Valencia. Valencia, Spain., Carrodeguas A; Gilead Sciences, Valencia, Spain., González-Sánchez JL; Gilead Sciences, Valencia, Spain., García-Deltoro M; Servicio de Enfermedades Infecciosas del Hospital General Universitario de Valencia. Universidad de Valencia. Valencia, Spain. Electronic address: miguel.garcia-deltoro@uv.es.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Sep; Vol. 146, pp. 107131. Date of Electronic Publication: 2024 Jun 11.
DOI:	10.1016/j.ijid.2024.107131
Abstrakt:	Objectives: Hepatitis B (HBV) and hepatitis C (HCV) viruses are significant causes of primary liver cancer, responsible for over a million deaths annually. We aimed to develop a screening strategy for viral hepatitis elimination in Spain, aligned with WHO's 2030 objectives. Design: The CRIVALVIR-FOCUS program, conducted at the Consortium General University Hospital of Valencia, aimed to identify individuals with active blood-borne viral infections through opportunistic population screening. The hospital's Health Department serves more than 280,000 adults. Results: Of the 31,995 adults screened (52% women; 15% immigrants), HBV prevalence was 0.44%, with higher rates in men (0.57%) than women (0.32%), and notably higher in migrants (1.27%) compared to Spanish nationals (0.30%). The 45-64 age group had the highest HBV prevalence (0.65%). HCV prevalence was 0.35%, again higher in men than women (0.51% vs 0.20%) and in migrants compared to Spanish nationals (0.58% vs 0.31%), with the 45-64 age group showing the highest HCV prevalence (0.76%). From the positive tests, 78.0% (110/141) of HBV cases and 71.4% (80/112) of HCV cases were patients previously unaware of their infections. Conclusion: Opportunistic screening effectively identifies early cases, potentially enhancing prevention of new infections. Our study highlights the need for targeted interventions for individuals aged 45-64 and migrants. Designing specific screening programs, in collaboration with social workers and cultural mediators, is critical to improve access to care. Training and involving primary care professionals are vital actions for the program's success. Competing Interests: Declaration of competing interest Alba Carrodeguas and José Luis González-Sánchez own shares in and are employees of Gilead Sciences. The remaining authors declare no conflicts of interest regarding this research, authorship, and publication of this article. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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