A comprehensive insight into the contribution of epigenetics in male infertility; focusing on immunological modifications.

Autor: Hsu CY; Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan., Jasim SA; Medical Laboratory Techniques Department, Al-Maarif University College, Anbar, Iraq. Electronic address: saade.a.j@uoa.edu.iq., Pallathadka H; Manipur International University, Imphal, Manipur, India., Kumar A; Department of Life Sciences, School of Sciences, Jain (Deemed-to-be) University, Bengaluru, Karnataka 560069, India; Department of Pharmacy, Vivekananda Global University, Jaipur, Rajasthan 303012, India., Konnova K; Assistant of the Department of Propaedeutics of Dental Diseases. Sechenov First Moscow State Medical University, Russia., Qasim MT; College of Health and Medical Technology, Al-Ayen University, Thi-Qar 64001, Iraq., Alubiady MHS; Department of Medical Engineering, Al-Hadi University College, Baghdad 10011, Iraq., Pramanik A; School of Applied and Life Sciences, Divison of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India., Al-Ani AM; Department of Medical Engineering, Al-Nisour University College, Baghdad, Iraq., Abosaoda MK; College of Technical Engineering, the Islamic University, Najaf, Iraq; College of Technical Engineering, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq; College of Technical Engineering, the Islamic University of Babylon, Babylon, Iraq.
Jazyk: angličtina
Zdroj: Journal of reproductive immunology [J Reprod Immunol] 2024 Aug; Vol. 164, pp. 104274. Date of Electronic Publication: 2024 Jun 04.
DOI: 10.1016/j.jri.2024.104274
Abstrakt: Numerous recent studies have examined the impact epigenetics-including DNA methylation-has on spermatogenesis and male infertility. Differential methylation of several genes has been linked to compromised spermatogenesis and/or reproductive failure. Specifically, male infertility has been frequently associated with DNA methylation abnormalities of MEST and H19 inside imprinted genes and MTHFR within non-imprinted genes. Microbial infections mainly result in male infertility because of the immune response triggered by the bacteria' accumulation of immune cells, proinflammatory cytokines, and chemokines. Thus, bacterially produced epigenetic dysregulations may impact host cell function, supporting host defense or enabling pathogen persistence. So, it is possible to think of pathogenic bacteria as potential epimutagens that can alter the epigenome. It has been demonstrated that dysregulated levels of LncRNA correlate with motility and sperm count in ejaculated spermatozoa from infertile males. Therefore, a thorough understanding of the relationship between decreased reproductive capacity and sperm DNA methylation status should aid in creating new diagnostic instruments for this condition. To fully understand the mechanisms influencing sperm methylation and how they relate to male infertility, more research is required.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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