Reproducibility Analysis of Radiomic Features on T2-weighted MR Images after Processing and Segmentation Alterations in Neuroblastoma Tumors.

Autor:	Veiga-Canuto D; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Fernández-Patón M; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Cerdà Alberich L; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Jiménez Pastor A; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Gomis Maya A; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Carot Sierra JM; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Sangüesa Nebot C; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Martínez de Las Heras B; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Pötschger U; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Taschner-Mandl S; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Neri E; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Cañete A; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Ladenstein R; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Hero B; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Alberich-Bayarri Á; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.)., Martí-Bonmatí L; From the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).
Jazyk:	angličtina
Zdroj:	Radiology. Artificial intelligence [Radiol Artif Intell] 2024 Jul; Vol. 6 (4), pp. e230208.
DOI:	10.1148/ryai.230208
Abstrakt:	Purpose To evaluate the reproducibility of radiomics features extracted from T2-weighted MR images in patients with neuroblastoma. Materials and Methods A retrospective study included 419 patients (mean age, 29 months ± 34 [SD]; 220 male, 199 female) with neuroblastic tumors diagnosed between 2002 and 2023, within the scope of the PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers (ie, PRIMAGE) project, involving 746 T2/T2*-weighted MRI sequences at diagnosis and/or after initial chemotherapy. Images underwent processing steps (denoising, inhomogeneity bias field correction, normalization, and resampling). Tumors were automatically segmented, and 107 shape, first-order, and second-order radiomics features were extracted, considered as the reference standard. Subsequently, the previous image processing settings were modified, and volumetric masks were applied. New radiomics features were extracted and compared with the reference standard. Reproducibility was assessed using the concordance correlation coefficient (CCC); intrasubject repeatability was measured using the coefficient of variation (CoV). Results When normalization was omitted, only 5% of the radiomics features demonstrated high reproducibility. Statistical analysis revealed significant changes in the normalization and resampling processes ( P < .001). Inhomogeneities removal had the least impact on radiomics (83% of parameters remained stable). Shape features remained stable after mask modifications, with a CCC greater than 0.90. Mask modifications were the most favorable changes for achieving high CCC values, with a radiomics features stability of 70%. Only 7% of second-order radiomics features showed an excellent CoV of less than 0.10. Conclusion Modifications in the T2-weighted MRI preparation process in patients with neuroblastoma resulted in changes in radiomics features, with normalization identified as the most influential factor for reproducibility. Inhomogeneities removal had the least impact on radiomics features. Keywords: Pediatrics, MR Imaging, Oncology, Radiomics, Reproducibility, Repeatability, Neuroblastic Tumors Supplemental material is available for this article. © RSNA, 2024 See also the commentary by Safdar and Galaria in this issue.
Databáze:	MEDLINE
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