| Autor: |
Li J; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China., Li J; Department of Radiology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, 420 Fu Ma Road, Fuzhou, Fujian 350001, China., Chen Y; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China., Tai P; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China., Fu P; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China., Chen Z; Key Laboratory of Coastal Environment and Resources of Zhejiang Province, School of Engineering, Westlake University, Hangzhou 310024, China., Yap PS; Department of Civil Engineering, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China., Nie Z; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China., Lu K; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China., He B; Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China. |
| Abstrakt: |
Drug-resistant bacterial infections pose a serious threat to human health; thus, there is an increasingly growing demand for nonantibiotic strategies to overcome drug resistance in bacterial infections. Mild photothermal therapy (PTT), as an attractive antibacterial strategy, shows great potential application due to its good biocompatibility and ability to circumvent drug resistance. However, its efficiency is limited by the heat resistance of bacteria. Herein, Cu 2 O@MoS 2 , a nanocomposite, was constructed by the in situ growth of Cu 2 O nanoparticles (NPs) on the surface of MoS 2 nanosheets, which provided a controllable photothermal therapeutic effect of MoS 2 and the intrinsic catalytic properties of Cu 2 O NPs, achieving a synergistic effect to eradicate multidrug-resistant bacteria. Transcriptome sequencing (RNA-seq) results revealed that the antibacterial process was related to disrupting the membrane transport system, phosphorelay signal transduction system, oxidative stress response system, as well as the heat response system. Animal experiments indicated that Cu 2 O@MoS 2 could effectively treat wounds infected with methicillin-resistant Staphylococcus aureus . In addition, satisfactory biocompatibility made Cu 2 O@MoS 2 a promising antibacterial agent. Overall, our results highlight the Cu 2 O@MoS 2 nanocomposite as a promising solution to combating resistant bacteria without inducing the evolution of antimicrobial resistance. |
