Heterogeneous Integration of Memristive and Piezoresistive MDMO-PPV-Based Copolymers in Nociceptive Transmission with Fast and Slow Pain for an Artificial Pain-Perceptual System.

Autor: Tsao SC; Department of Electronic Engineering, Chang Gung University, Guishan Dist., Taoyuan, 33302, Taiwan., Chang KH; Department of Neurology, Chang Gung Memorial Hospital, Linkou, Guishan Dist., Taoyuan, 33305, Taiwan.; College of Medicine, Chang Gung University, Guishan Dist., Taoyuan, 33302, Taiwan., Fu Y; Department of Electronic Engineering, Chang Gung University, Guishan Dist., Taoyuan, 33302, Taiwan., Tai HH; Department of Electronic Engineering, Chang Gung University, Guishan Dist., Taoyuan, 33302, Taiwan., Lin TH; Department of Chemical and Materials Engineering, Chang Gung University, Guishan Dist., Taoyuan, 33302, Taiwan., Wu MC; Department of Chemical and Materials Engineering, Chang Gung University, Guishan Dist., Taoyuan, 33302, Taiwan.; Center for Sustainability and Energy Technologies, Chang Gung University, Guishan Dist., Taoyuan, 33302, Taiwan.; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Guishan Dist., Taoyuan, 33305, Taiwan., Wang JC; Department of Electronic Engineering, Chang Gung University, Guishan Dist., Taoyuan, 33302, Taiwan.; Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou, Guishan Dist., Taoyuan, 33305, Taiwan.; Department of Electronic Engineering, Ming Chi University of Technology, Taishan Dist., New Taipei City, 243303, Taiwan.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Oct; Vol. 20 (42), pp. e2311040. Date of Electronic Publication: 2024 Jun 12.
DOI: 10.1002/smll.202311040
Abstrakt: Nociceptive pain perception is a remarkable capability of organisms to be aware of environmental changes and avoid injury, which can be accomplished by specialized pain receptors known as nociceptors with 4 vital properties including threshold, no adaptation, relaxation, and sensitization. Bioinspired systems designed using artificial devices are investigated to imitate the efficacy and functionality of nociceptive transmission. Here, an artificial pain-perceptual system (APPS) with a homogeneous material and heterogeneous integration is proposed to emulate the behavior of fast and slow pain in nociceptive transmission. Retention-differentiated poly[2-methoxy-5-(3,7-dimethyoctyoxyl)-1,4-phenylenevinylene] (MDMO-PPV) memristors with film thicknesses of 160 and 80 nm are manufactured and adopted as A-δ and C nerve fibers of nociceptor conduits, respectively. Additionally, a nociceptor mimic, the ruthenium nanoparticles (Ru-NPs)-doped MDMO-PPV piezoresistive pressure sensor, is fabricated with a noxiously stimulated threshold of 150 kPa. Under the application of pricking and dull noxious stimuli, the current flows predominantly through the memristor to mimic the behavior of fast and slow pain, respectively, in nociceptive transmission with postsynaptic potentiation properties, which is analogous to biological pain perception. The proposed APPS can provide potential advancements in establishing the nervous system, thus enabling the successful development of next-generation neurorobotics, neuroprosthetics, and precision medicine.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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