Exploring the multifaceted role of direct interaction between cancer cells and fibroblasts in cancer progression.
| Autor: | Dhungel N; Department of Molecular and Cellular Physiology, LSUHSC, Shreveport, LA, United States., Dragoi AM; Department of Molecular and Cellular Physiology, LSUHSC, Shreveport, LA, United States.; Feist-Weiller Cancer Center, INLET Core, LSUHSC, Shreveport, LA, United States. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in molecular biosciences [Front Mol Biosci] 2024 May 28; Vol. 11, pp. 1379971. Date of Electronic Publication: 2024 May 28 (Print Publication: 2024). |
| DOI: | 10.3389/fmolb.2024.1379971 |
| Abstrakt: | The interaction between the tumor microenvironment (TME) and the cancer cells is a complex and mutually beneficial system that leads to rapid cancer cells proliferation, metastasis, and resistance to therapy. It is now recognized that cancer cells are not isolated, and tumor progression is governed among others, by many components of the TME. The reciprocal cross-talk between cancer cells and their microenvironment can be indirect through the secretion of extracellular matrix (ECM) proteins and paracrine signaling through exosomes, cytokines, and growth factors, or direct by cell-to-cell contact mediated by cell surface receptors and adhesion molecules. Among TME components, cancer-associated fibroblasts (CAFs) are of unique interest. As one of the most abundant components of the TME, CAFs play key roles in the reorganization of the extracellular matrix, facilitating metastasis and chemotherapy evasion. Both direct and indirect roles have been described for CAFs in modulating tumor progression. In this review, we focus on recent advances in understanding the role of direct contact between cancer cells and cancer-associated fibroblasts (CAFs) in driving tumor development and metastasis. We also summarize recent findings on the role of direct contact between cancer cells and CAFs in chemotherapy resistance. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Dhungel and Dragoi.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|