Non-invasive assessment of left ventricular contractility by myocardial work index in veno-arterial membrane oxygenation patients: rationale and design of the MIX-ECMO multicentre observational study.

Autor:	Lakatos BK; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Ladányi Z; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Fábián A; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Ehrenberger R; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Turschl T; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Bagyura Z; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Evrard B; Medical-Surgical ICU, Dupuytren Teaching Hospital, Limoges, France.; Inserm CIC 1435, Dupuytren Teaching Hospital, Limoges, France., Vandroux D; Cardiothoracic Intensive Care Unit, Dupuytren University Hospital, Limoges, France.; Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of Chronic Diseases in Tropical Zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France., Goudelin M; Medical-Surgical ICU, Dupuytren Teaching Hospital, Limoges, France., Lindner S; Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; European Center for AngioScience (ECAS), German Center for Cardiovascular Research (DZHK) Partner Site Heidelberg/ Mannheim, and Centre for Cardiovascular Acute Medicine Mannheim (ZKAM), Medical Centre Mannheim, Heidelberg University, Mannheim, Germany., Britsch S; Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; European Center for AngioScience (ECAS), German Center for Cardiovascular Research (DZHK) Partner Site Heidelberg/ Mannheim, and Centre for Cardiovascular Acute Medicine Mannheim (ZKAM), Medical Centre Mannheim, Heidelberg University, Mannheim, Germany., Dürschmied D; Cardiology, Angiology, Haemostaseology, and Medical Intensive Care, Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; European Center for AngioScience (ECAS), German Center for Cardiovascular Research (DZHK) Partner Site Heidelberg/ Mannheim, and Centre for Cardiovascular Acute Medicine Mannheim (ZKAM), Medical Centre Mannheim, Heidelberg University, Mannheim, Germany., Zima E; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Csikós GR; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Túróczi Z; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Soltész Á; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Németh E; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Kovács A; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.; Department of Experimental and Surgical Techniques, Semmelweis University, Budapest, Hungary., Édes FI; Heart and Vascular Center, Semmelweis University, Budapest, Hungary., Merkely B; Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 May 28; Vol. 11, pp. 1399874. Date of Electronic Publication: 2024 May 28 (Print Publication: 2024).
DOI:	10.3389/fcvm.2024.1399874
Abstrakt:	Introduction and Aims: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an increasingly utilized therapeutic choice in patients with cardiogenic shock, however, high complication rate often counteracts with its beneficial cardiopulmonary effects. The assessment of left ventricular (LV) function in key in the management of this population, however, the most commonly used measures of LV performance are substantially load-dependent. Non-invasive myocardial work is a novel LV functional measure which may overcome this limitation and estimate LV function independent of the significantly altered loading conditions of VA-ECMO therapy. The Usefulness of Myocardial Work IndeX in ExtraCorporeal Membrane Oxygenation Patients (MIX-ECMO) study aims to examine the prognostic role of non-invasive myocardial work in VA-ECMO-supported patients. Methods: The MIX-ECMO is a multicentric, prospective, observational study. We aim to enroll 110 patients 48-72 h after the initiation of VA-ECMO support. The patients will undergo a detailed echocardiographic examination and a central echocardiography core laboratory will quantify conventional LV functional measures and non-invasive myocardial work parameters. The primary endpoint will be failure to wean at 30 days as a composite of cardiovascular mortality, need for long-term mechanical circulatory support or heart transplantation at 30 days, and besides that other secondary objectives will also be investigated. Detailed clinical data will also be collected to compare LV functional measures to parameters with established prognostic role and also to the Survival After Veno-arterial-ECMO (SAVE) score. Conclusions: The MIX-ECMO study will be the first to determine if non-invasive myocardial work has added prognostic value in patients receiving VA-ECMO support. Competing Interests: BKL, AF and AK report personal fees from Argus Cognitive Inc., outside the submitted report. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 Lakatos, Ladányi, Fábián, Ehrenberger, Turschl, Bagyura, Evrard, Vandroux, Goudelin, Lindner, Britsch, Dürschmied, Zima, Csikós, Túróczi, Soltész, Németh, Kovács, Édes and Merkely.)
Databáze:	MEDLINE
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