Assessment of leukocyte and systemic inflammation index ratios in dyslipidemia patients with dry eye disease: a retrospective case‒control study.

Autor: Alhalwani AY; College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. halwania@ksau-hs.edu.sa.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. halwania@ksau-hs.edu.sa., Hafez SY; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.; College of Nursing, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia., Alsubaie N; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia., Rayani K; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia., Alqanawi Y; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia., Alkhomri Z; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia., Hariri S; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia., Jambi S; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.; College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Jazyk: angličtina
Zdroj: Lipids in health and disease [Lipids Health Dis] 2024 Jun 11; Vol. 23 (1), pp. 179. Date of Electronic Publication: 2024 Jun 11.
DOI: 10.1186/s12944-024-02176-z
Abstrakt: Background: Dry eye disease (DED) is a complication of dyslipidemia (DLP) that is caused by metabolic syndrome and increased inflammation. This research aimed to assess leukocyte and systemic inflammation index ratios as potential biomarkers for systemic inflammation in dyslipidemia patients with dry eye disease (DLP-DED).
Methods: Several blood biomarkers were studied in 32 patients with DLP-DED (study group) and 63 patients with DLP-only (control group). The evaluated blood biomarkers included specific systemic inflammation index ratios, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte and platelet ratio (NLPR), and lipid profiles, such as total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglyceride (TG), albumin (ALB), and C-reactive protein (CRP) levels.
Results: Lymphocyte levels were significantly greater in the DLP-DED group than in the DLP-only group (P = 0.044). In addition, a significant negative correlation between HDL and the NLPR (P = 0.007; r= -0.428) and a significant negative correlation between the serum ALB concentration and the PLR (P = 0.008; r= -0.420) were identified as potential inflammatory predictors of DLP-DED.
Conclusion: The findings of this study suggest that patients with DLP-DED may benefit from routine blood monitoring of their elevated lipid profile and blood inflammatory biomarkers, such as CRP, leukocytes, and systemic inflammation index ratios (NLR, PLR, MLR, and NLPR), to reduce the complications of DLP on ocular health. The correlation data suggest that the NLPR, PLR, serum ALB concentration, and serum HDL concentration may be valuable inflammatory biomarkers in DLP-DED patients. More research is required to ascertain the significance of the NLR, PLR, MLR, and NLPR and the additive role that leukocytes play.
(© 2024. The Author(s).)
Databáze: MEDLINE
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