Pioneering Topical Ointment Intervention for Unprecedented Antimicrobial and Diabetic Wound Management with Phenylpropanoids and Nano-Silver.

Autor: Nagaiah HP; Department of Biotechnology, Alagappa University, Karaikudi, India., Periyakaruppan Murugesan PD; Department of Biotechnology, Alagappa University, Karaikudi, India., Ravindra Rupali CV; Department of Biotechnology, Alagappa University, Karaikudi, India., Shunmugiah KP; Department of Biotechnology, Alagappa University, Karaikudi, India. pandiansk@alagappauniversity.ac.in.
Jazyk: angličtina
Zdroj: The AAPS journal [AAPS J] 2024 Jun 11; Vol. 26 (4), pp. 67. Date of Electronic Publication: 2024 Jun 11.
DOI: 10.1208/s12248-024-00936-4
Abstrakt: Addressing the intertwined challenges of antimicrobial resistance and impaired wound healing in diabetic patients, an oil/water emulsion-based nano-ointment integrating phenylpropanoids-Eugenol and Cinnamaldehyde-with positively-charged silver nanoparticles was synthesized. The process began with the synthesis and characterization of nano-silver, aimed at ensuring the effectiveness and safety of the nanoparticles in biological applications. Subsequent experiments determined the minimum inhibitory concentration (MIC) against pathogens such as Streptococcus aureus, Pseudomonas aeruginosa and Candida albicans. These MIC values of all three active leads guided the strategic formulation of an ointment base, which effectively integrated the bioactive components. Evaluations of this nano-ointment revealed enhanced antimicrobial activity against both clinical and reference bacterial strains and it maintained stability after freeze-thaw cycles. Furthermore, the ointment demonstrated superior in-vitro diabetic wound healing capabilities and significantly promoted angiogenesis, as shown by enhanced blood vessel formation in the Chorioallantoic Membrane assay. These findings underscore the formulation's therapeutic potential, marking a significant advance in the use of nanotechnology for topical wound care.
(© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.)
Databáze: MEDLINE
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